Involvement of concentration-sensitive sodium channel in alveolar fluid clearance

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Physiological roles of concentration-sensitive sodium channels (Na_C : c=concentration) expressed in mouse alveolar epithelial cells are not yet known. In this study, we investigated the role of Na_C in alveolar fluid clearance. Na_C expression dramatically decreased in the lung during inflammation induced by lipopolysaccharide. Lung fluid content increased during early inflammation and decreased after the recovery of Na_C expression. These results suggested that LPS-induced suppression of Na_C in alveolar epithelial cells reduced AFC and caused the increase in lung fluid content in acute lung injury.