Analysis of the functions of the PAR-aPKC complex in the regulation of the slit diaphragm proteins

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The prevalence of end-stage renal disease (ESRD) in Japan have reached more than 290,000 by the end of 2009 and is still increasing by 10,000 a year. Although glomerular diseases cause about 80% of ESRD, the mechanisms of the pathophysiology and progression of glomerular diseases are still obscure. To resolve this situation, I established a new mouse line with a glomerular disease based on the disturbance in podocyte cell polarity and revealed a new aspect of the molecular mechanisms to maintain glomerular filtration function. These results would contribute to our understanding of the molecular pathophysiology of glomerular diseases and to the innovation of diagnostic techniques or medical interventions.