Analysis of the functions of the PAR-aPKC complex in the regulation of the slit diaphragm proteins

PAR-aPKC复合物调控裂隙隔膜蛋白的功能分析

• 批准号: 20790261
• 负责人: HIROSE Tomonori
• 金额: $ 2.75万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790261/
• 关键词: シグナル伝達; 疾患モデル動物; 糸球体疾患; 細胞極性; 腎臓病

The prevalence of end-stage renal disease (ESRD) in Japan have reached more than 290,000 by the end of 2009 and is still increasing by 10,000 a year. Although glomerular diseases cause about 80% of ESRD, the mechanisms of the pathophysiology and progression of glomerular diseases are still obscure. To resolve this situation, I established a new mouse line with a glomerular disease based on the disturbance in podocyte cell polarity and revealed a new aspect of the molecular mechanisms to maintain glomerular filtration function. These results would contribute to our understanding of the molecular pathophysiology of glomerular diseases and to the innovation of diagnostic techniques or medical interventions.

截至2009年底，日本终末期肾病（ESRD）的患病率已超过29万，并仍在以每年1万的速度增长。虽然肾小球疾病导致约80%的ESRD，但肾小球疾病的病理生理和进展机制仍不清楚。为了解决这一问题，我建立了一种基于足细胞极性紊乱的肾小球疾病小鼠新系，揭示了维持肾小球滤过功能的分子机制的新方面。这些结果将有助于我们对肾小球疾病的分子病理生理学的理解，并有助于诊断技术或医疗干预的创新。

项目成果

Apoptosis-Stimulating Protein of p53 (ASPP2) is involved in the PAR Complex to Regulate Epithelial Cell Polarity.

p53 凋亡刺激蛋白 (ASPP2) 参与 PAR 复合物调节上皮细胞极性。

• 发表时间: 2010
• 作者: Cong W*;○Hirose T*;Harita Y;Yamashita A;Mizuno K;Hirano H;Ohno S.(*equally contributed).
• 通讯作者: Ohno S.(*equally contributed).

腎糸球体ポドサイトの糸球体濾過膜維持の新しい分子機構:細胞極性制御系aPKC-PAR系の役割

维持肾小球足细胞肾小球滤过膜的新分子机制：细胞极性控制系统aPKC-PAR系统的作用

• 发表时间: 2009
• 作者: 廣瀬智威;佐藤大輔;栗原秀剛;日下智保;廣瀬博子;秋本和憲;松阪泰二;市川家國;伊藤秀一;野田哲生;大野茂男
• 通讯作者: 大野茂男

A cell polarity protein, aPKCλ, plays a critical role on the maintenance of podocyte slit diaphragm

细胞极性蛋白 aPKCλ 在足细胞裂隙隔膜的维持中发挥关键作用

• 发表时间: 2008
• 作者: ○廣瀬智威;佐藤大輔;栗原秀剛;松阪泰二;秋本和憲;市川家國;野田哲生;大野茂男;廣瀬智威
• 通讯作者: 廣瀬智威

aPKC restricts the basolateral determinant Ptdlns(3,4,5)P3 to the basal region

aPKC 将基底外侧决定簇 Ptdlns(3,4,5)P3 限制在基底区域

• 发表时间: 2008
• 期刊: Biochemical and Biophysical Research Communications 368
• 作者: Takahama;S.;et. al.
• 通讯作者: et. al.

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

• DOI: 10.1093/ndt/gfq058
• 发表时间: 2010-08-01
• 期刊: NEPHROLOGY DIALYSIS TRANSPLANTATION
• 影响因子: 6.1
• 作者: Machida, Hiroyuki;Ito, Shuichi;Yokota, Shumpei
• 通讯作者: Yokota, Shumpei