The role of allograft aging and senescence in allograft dysfunction after liver transplantation

点击翻译按钮获取中文摘要

This is the first study to compare stable human liver allografts versus chronically rejected allografts in the long-term after liver transplantation from the viewpoint of genomic instability, specially telomere shortening, chimerism, and aneuploidy. The telomere decline at 10 years post-transplant, the telomere decline rate at the first year after transplantation, and hepatocellular aneuploidy at 10 years post-transplant were seen greater in rejection group than those of stable group, although advanced aneuploidy and telomere shortening for the presumed allograft age was seen in both groups.