Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)

乙型肝炎 e 抗原 (HBeAg) 抑制免疫 Toll 样受体 (TLR) 信号转导

• 批准号: nhmrc : 491017
• 负责人: A/Pr Ashley Mansell
• 金额: $ 36.16万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/suppression-immune-toll-antigen-hbeag/95714
• 关键词: Suppression; Immune; Toll; like; receptor

Hepatitis B virus (HBV) infection is a major world-wide health problem, which the current treatment strategies are not ideal. Therefore understanding how HBV inteacts with the immune system is of critical importance to developing intervention strategies to promote better health outcomes. This grant will develop our novel findings that a protein produced by HBV 'blinds' the host immune system by producing a protein that blocks the innate immune response to allow HBV to replicate unchallenged.

B型肝炎病毒（HBV）感染是一个世界性的重大健康问题，目前的治疗策略并不理想。因此，了解HBV如何与免疫系统相互作用对于制定干预策略以促进更好的健康结果至关重要。这项资助将发展我们的新发现，即HBV产生的一种蛋白质通过产生一种阻止先天免疫反应的蛋白质来“蒙蔽”宿主免疫系统，使HBV能够不受挑战地复制。