Non-invasive evaluation of the pulmonary hypertension and inhibition of pulmonary vascular remodeling by bosentan.

我们测量了各种血液生物标志物来评估肺动脉高压的进展。肺动脉高压患者血清BNP和NT-proBNP明显升高，是心力衰竭的标志。肺动脉高压等右心室压力过载导致心肌胶原代谢指标PIIIP升高。高敏感性肌钙蛋白I （cTnI）是肺动脉高压患者心肌损伤最敏感的标志物。此外，血清cTnI水平与肺系统血压比（Pp/Ps）显著相关。

We measured various kinds of blood biomarkers to evaluate the progression of pulmonary hypertension. Serum BNP and NT-proBNP which are known as heart failure marker were significantly increased in patients with pulmonary hypertension. PIIIP which is a marker of the myocardial collagen metabolism was increased by right ventricle pressure overload such as pulmonary hypertension. High sensitivity troponin I (cTnI) which is the most sensitive marker of the myocardial injury was significantly increased in patients with pulmonary hypertension. Furthermore, serum cTnI levels significantly correlated with pulmonary systemic blood pressure ratio (Pp/Ps).