Non-invasive evaluation of the pulmonary hypertension and inhibition of pulmonary vascular remodeling by bosentan.

我们检测了各种血液生物标志物，以评估肺动脉高压的进展。作为心力衰竭标志物的血清BNP和NT-proBNP在肺动脉高压患者中显著升高。PIIIP是心肌胶原代谢的标志物，在右室压力超负荷的情况下，如肺动脉高压，PIIIP明显增加。高敏肌钙蛋白I(CTnI)是反映心肌损伤最敏感的指标，在肺动脉高压患者中明显升高。此外，血清cTnI水平与肺体循环压比值(PP/Ps)显著相关。

We measured various kinds of blood biomarkers to evaluate the progression of pulmonary hypertension. Serum BNP and NT-proBNP which are known as heart failure marker were significantly increased in patients with pulmonary hypertension. PIIIP which is a marker of the myocardial collagen metabolism was increased by right ventricle pressure overload such as pulmonary hypertension. High sensitivity troponin I (cTnI) which is the most sensitive marker of the myocardial injury was significantly increased in patients with pulmonary hypertension. Furthermore, serum cTnI levels significantly correlated with pulmonary systemic blood pressure ratio (Pp/Ps).