Immunological examination and efficacy of immunomodulator in pediatric inflammatory bowel disease

小儿炎症性肠病的免疫学检查及免疫调节剂的疗效

• 批准号: 20790747
• 负责人: FUJII Toru
• 金额: $ 2.25万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790747/
• 关键词: 炎症性腸疾患; 免疫調節薬; サイトカイン

In recent years, the lowering of the age of the inflammatory bowel disease is advanced and it is thought that the change in eating habits and the hygienic environment takes part greatly. The objective of this study was to examine the change in immunity and the efficacy of immunomodulatory agents in pediatric inflammatory bowel disease in developing process. Significant elevation of serum Il-4 and Il-6 levels was detected at the acute phase of pediatric UC and CD patients compared with levels at the remission. The mucosal expression of GATA-3 and STAT-4 were significantly enhanced in the acute phase of pediatric UC patients compared with normal mucosa. These results suggest that IL-4 and its signaling molecule GATA-3, as well as the Th1 signaling molecule STAT-4, are involved in the pathogenesis of acute phase of pediatric UC. The doses of 6-MP need to maintain remission in Japanese children are lower than those reported in Western countries. However, 6-TGN concentrations in this population are higher than those previously reported. It is thought to be affected by the differences in racial metabolizing and the usage of other medicines.

近年来，炎症性肠病发病年龄的降低正在推进，人们认为饮食习惯和卫生环境的改变在很大程度上起着作用。本研究旨在探讨小儿炎症性肠病发病过程中免疫功能的变化及免疫调节剂的疗效。在儿童UC和CD患者急性期检测到血清IL-4和IL-6水平显著升高，与缓解期水平相比。与正常黏膜相比，儿童UC患者急性期黏膜中加塔-3和STAT-4的表达明显增强。提示IL-4及其信号分子加塔-3和Th 1信号分子STAT-4参与了儿童UC急性期的发病过程。日本儿童维持缓解所需的6-MP剂量低于西方国家报道的剂量。然而，该人群中的6-TGN浓度高于先前报告的浓度。它被认为是受种族代谢和其他药物使用差异的影响。

项目成果

小児炎症性腸疾患における免疫調節薬の検討

免疫调节药物治疗小儿炎症性肠病的研究

• 发表时间: 2008
• 作者: Ohtsuka Y;Fujii T;et al.;藤井徹;藤井徹;藤井徹
• 通讯作者: 藤井徹

Monitoring 6‐thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease

• DOI: 10.1111/j.1440-1746.2010.06364.x
• 发表时间: 2010-10
• 期刊: Journal of Gastroenterology and Hepatology
• 影响因子: 4.1
• 作者: Y. Ohtsuka;K. Arai;Y. Aoyagi;T. Fujii;Yoko Yamakawa;Kiyotaka Ohtani;T. Ikuse;Y. Baba;Eisuke Inage-Eis

当科におけるCrohn病の治療経過

我科克罗恩病治疗进展

• 发表时间: 2009
• 作者: Ohtsuka Y;Fujii T;et al.;藤井徹
• 通讯作者: 藤井徹