analysis of function about keratinocyte differentiation of p51/p63, homologue of tumor suppressor gene p53

抑癌基因p53同源物p51/p63角化细胞分化功能分析

• 批准号: 20790786
• 负责人: OKAWA Eisaku
• 金额: $ 2.5万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790786/
• 关键词: 発生・分化; 表皮細胞分化; p51; p63; p53

I found that p63 was related to the mechanism of keratin 1 expression in keratinocyte differentiation. p63 induces keratin 1 via JNK/AP-1 activation. I explained keratinocyte growth factor, from dermal fibroblast, suppressed keratin 1 expression via ERK signaling.I examined the relationship between p63 and sonic hedgehog. I overexpressed p63 in keratinocyte and showed the promoter activity of sonic hedgehog increased. In vivo, I showed that p63 expressed strongly in basal cell carcinoma by immunostaining method.

我发现p63与角蛋白1在角质形成细胞分化中的表达机制有关。P63通过激活JNK/AP-1来诱导角蛋白1的表达。我解释了来自真皮成纤维细胞的角质形成细胞生长因子通过ERK信号抑制角蛋白1的表达。我研究了p63与声波刺猬的关系。I在角质形成细胞中过表达p63，显示声波刺猬的启动子活性增强。在体内，免疫组织化学染色显示p63在基底细胞癌中呈强阳性表达。

项目成果

Notch2 down-regulation in wound healing is contributed to acceleration of cell motility

Notch2在伤口愈合中的下调有助于加速细胞运动

• 发表时间: 2009
• 作者: 奥山隆平;斉藤るみ子;小川英作;井川俊太郎;相場節也
• 通讯作者: 相場節也

Cutaneous accumulation of abnormal polyglutamine proteins of patients with dentatorubral‐pallidoluysian atrophy

齿状红核-苍白路易体萎缩患者皮肤异常聚谷氨酰胺蛋白的积累

• DOI: 10.1111/j.1468-1331.2009.02658.x
• 发表时间: 2009
• 期刊: European Journal of Neurology
• 影响因子: 5.1
• 作者: M. Ohta;Ryuhei Okuyama;E. Ogawa;K. Kisu;H. Sato;Masashi Aoki;Setsuya Aiba
• 通讯作者: Setsuya Aiba

p63 prevents growth arrest via Sonic hedgehog induction

p63 通过 Sonic hedgehog 诱导防止生长停滞

• 发表时间: 2009
• 作者: 小川英作;奥山隆平;岡田修子;井川俊太郎;相場節也
• 通讯作者: 相場節也

p63/p51-induced Onset of Keratinocyte Differentiation via the c-Jun N-terminal Kinase Pathway Is Counteracted by Keratinocyte Growth Factor

• DOI: 10.1074/jbc.m804101200
• 发表时间: 2008-12-05
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Ogawa, Eisaku;Okuyama, Ryuhei;Aiba, Setsuya
• 通讯作者: Aiba, Setsuya