Development of shortened PET measurement method for investigation of the dopamine function in psychiatric disorders

开发用于研究精神疾病中多巴胺功能的缩短 PET 测量方法

• 批准号: 20790839
• 负责人: IKOMA Yoko
• 金额: $ 2.16万
• 依托单位: Nara Institute of Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790839/
• 关键词: PET; ドーパミン; 受容体; 結合能; [^<11>C]raclopride; 複数回投与法; [^<11>C]racloride

1回のPET検査で複数回の放射性薬剤を投与する複数回投与法を用い、短時間で簡便にドーパミンD_2受容体密度を測定する新しい手法を開発した。50分間隔で3回[^<11>C]racloprideを投与する測定プロトコルを確立し、シミュレーションによって受容体密度の推定精度を評価した結果、推定値は真値に比べやや過大評価されたものの、推定値と真値は良い相関を示した。また、本手法を用いたサルのPET検査においても、得られた受容体密度は従来法による値と類似しており、本手法の妥当性が確認された。本手法により、150分のPET検査でドーパミンD_2受容体密度を測定することが可能となった。

1. Return the PET to copy the number of radionuclides and the number of copies to return to use the method, and use it for a short period of time to test the bulk density of D2 capacitors. At intervals of 50 minutes, [^ & lt;11>C] raclopride is used to determine the accuracy of the volume density, the accuracy of the presumption of the bulk density, the accuracy of the presumption of the bulk density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the bulk density, the accuracy of the presumption, the accuracy of the test, the accuracy of the presumption of the bulk density, the accuracy of the presumption of the bulk density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the volume density, the accuracy of the presumption of the volume density, the accuracy of the presumption of In this technique, we use the method to determine the volume density of the capacitive volume, and to confirm the appropriateness of this technique. This technique is used to determine the bulk density of D _ 2 capacitive volume in PET. It is possible that the volume density of the D2 capacitive volume is measured.

项目成果

Quantitative assessment of changes in binding potential with reference tissue model and multiple injection of [^<11>C]radopride

与参考组织模型和多次注射[^ 11 C]radopride的结合潜力变化的定量评估

• 发表时间: 2008
• 作者: Ikoma Y;Watabe H;Hayashi T;Iida H;Ikoma Yoko
• 通讯作者: Ikoma Yoko

[^<11>C]raclopride複数回投与によるPETを用いた受容体結合能変化の短時間測定

[^ 11 C]雷氯必利多次给药后使用PET短期测量受体结合能力的变化

• 发表时间: 2008
• 作者: 生駒洋子;渡部浩司;林拓也;湊小太郎;飯田秀博
• 通讯作者: 飯田秀博

Quantitative assessment of changes in binding potential with reference tissue model and multiple injection of [^<11>C]raclopride

与参考组织模型和多次注射[^11C]雷氯必利结合电位变化的定量评估

• 发表时间: 2008
• 作者: Ikoma Y;Watabe H;Hayashi T;Iida H
• 通讯作者: Iida H