A study on the pathophysiology of dementia with Lewy bodies (DLB) and the usefulness of Yokukan-san for the treatment of DLB and its functional mechanism

我们探讨了脑SPECT脑灌注断层扫描统计分析程序在路易体痴呆临床诊断中的作用，并在MIBG心肌显像上证实了枕叶低灌注与帕金森病、立位性低血压和心纵隔(H/M)比值的关系。这些结果提示自主神经功能障碍在DLB的病理生理学中起重要作用。用原代培养大鼠皮质神经元进行的体外研究表明，横断散对β-淀粉样蛋白(A-β)诱导的细胞毒性具有神经保护作用。

We examined the usefulness of statistical analysis programs of brain perfusion SPECT for the clinical diagnosis of dementia with Lewy bodies (DLB) and demonstrated the relation between occipital hypoperfusion and Parkinsonism, and orthostatic hypotension and the heart-to-mediastinum (H/M) ratio on MIBG myocardial scintigraphy. These results suggest that autonomic dysfunction plays an important role in the pathophysiology of DLB. In vitro study using primary culture of rat cortical neuron indicated that Yokukan-san had neuroprotective effect against beta amyloid protein (Aβ)-induced cytotoxicity.