A study on the pathophysiology of pervasive developmental disorder and development of diagnostic support tool from a viewpoint of gender difference

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The Prisoner's Dilemma illustrates the paradoxical disposition of interaction between two individuals with opposing interests. We investigated the cognitive characteristics of Pervasive Developmental Disorder(PDD) by using a game based on this dilemma and demonstrated that the subjects with PDD had lower awareness to the others compared to the controls. Prenatal exposure to high dose ethanol causes various sequelae in the child including decreased social interaction. We performed transvenous transplantation of neural stem cells to the Fetal Alcohol Spectrum Disorders model rat and observed the improvement of the results of social interaction test. These results suggest that repair of neural network damage could be related to clinical symptoms in PDD.