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Transcriptional regulation of orexin by candidate genes for narcolepsy

Transcriptional regulation of orexin by candidate genes for narcolepsy
发作性睡病候选基因对食欲素的转录调节
批准号:
20790868
负责人:
TANAKA Susumu
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
In this study, I examined the activities of transcriptional modulations of two narcolepsy candidate genes, IGFBP3 and NR6A1, against ORX transcription. (1)IGFBP3 and NR6A1 expression were found in hypothalamic ORX neurons by immunehistochemical studies. (2)By using reporter assay, IGFBP3 and NR6A1 modulated ORX promoter activity in several cell lines. (3)IGFBP3 overexpression mice showed the reduction of hypothalamic ORX expression and modulated sleep conditions. I also found NR6A1 overexpression modulated ORX expression, however the mice number examined have not reached statistically enough yet.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [田中進, 児玉亨, 本多芳子, 臼井節夫, 本多真]
通讯作者: 本多真
HLA gene expression in white blood cells of narcolepsy.
发作性睡病白细胞中 HLA 基因的表达。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Honda M, Tanaka S, Honda Y]
通讯作者: Honda Y
DOI: 10.1038/jhg.2009.118
发表时间: 2010-01-01
期刊: JOURNAL OF HUMAN GENETICS
影响因子: 3.5
作者: [Miyagawa, Taku, Honda, Makoto, Tokunaga, Katsushi]
通讯作者: Tokunaga, Katsushi
DOI: 10.1016/j.jcv.2008.07.011
发表时间: 2008-11-01
期刊: JOURNAL OF CLINICAL VIROLOGY
影响因子: 8.8
作者: [Matsunaga, Hidenori, Tanaka, Susumu, Takeda, Masatoshi]
通讯作者: Takeda, Masatoshi
22
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