Analysis of neural mechanism within brainstem related to the pathogenesis of bruxism and oral dyskinesia.

在这项研究中，我们研究了与睡眠磨牙和口腔运动障碍发病机制相关的三叉神经元膜特性。谷氨酸、5-羟色胺、食欲素等神经递质可抑制大鼠三叉神经中脑神经元的膜性质，而这些递质可增加三叉神经运动神经元的膜兴奋性。免疫染色形态学研究也显示发育性神经递质受体表达增加。这些结果分别显示了三叉神经网络对运动系统和感觉系统的差异调节作用。有趣的是，一些异常，如变性受体对神经递质的敏感性，可能会破坏运动和感觉输入之间的协调方式的调节，从而导致口腔运动功能障碍。

In this study, we examined the membrane properties in trigeminal neurons related to the pathogenesis of sleep bruxism and oral dyskinesia. Application of Glutamate, 5-HT or Orexin, one of neurotransmitters, suppressed membrane properties of rat trigeminal mesencephalic neurons, while those transmitters increased the membrane excitability in trigeminal motoneurons. Morphological study using immunostaining also revealed the developmental increase of receptor expressions of neurotransmitters examined in this study. These results show the differential modulatory effects on motor and sensory system in trigeminal network independently. It is interesting to speculate that some abnormalities such as denatured receptor sensitivity to neurotransmitters might disrupt regulation in a coordinate manner between motor and sensory inputs and exert oral motor dysfunction.