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Study of the effect of rare metals on iNKT cells by molecular nutritional procedure

Study of the effect of rare metals on iNKT cells by molecular nutritional procedure
通过分子营养程序研究稀有金属对 iNKT 细胞的影响
批准号:
21500789
负责人:
TANAKA Susumu
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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英文摘要
In vitro screening was performed for trace elements and rare metals that influence the enzyme activity of calcineurin(CN), which is involved in cellular immunity. Manganese(Mn^<2+>) noncompetitively inhibited nickel(Ni^<2+>)-stimulated CN activity, and the rare earth lanthanum(La^<3+>) increased CN activity. Next, the influence of vanadium ion(VO)^<3->_4) on the production of interleukin-2(IL-2)(an indicator of cellular immunity) was investigated using the human T-cell line Jurkat cells. This showed that NADPH oxidase-mediated VO^<3->_4induced IL-2 production in Jurkat T-cells.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [田中進, 増田泰紀, 田中佑季, 本間千裕, 高橋克典, 保坂公平, 久保原禅]
通讯作者: 久保原禅
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [田中進, 田中佑季]
通讯作者: 田中佑季
DOI: --
发表时间: 2009
期刊: 微量栄養素研究
影响因子: --
作者: [田中佑季, 大塚恵美子, 保坂公平, 田中進]
通讯作者: 田中進
Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells
锰通过激活 Jurkat T 细胞中的 AP-1 促进佛波酯诱导的白细胞介素 2 的产生
DOI: 10.1016/j.toxlet.2012.04.015
发表时间: 2012
期刊: Toxicology Letters
影响因子: 3.5
作者: [Tanaka S, Masuda Y, Honma C, Hosaka K, Takahashi K, & Kubohara Y]
通讯作者: & Kubohara Y
6
    Effect of alkylbenzene sulfonate, the major component of synthetic laundry detergent, on immunity
    • 批准号:
      18K02259
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2018
    • 负责人:
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      16K08533
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    • 资助金额:
      $3.0万
    • 财政年份:
      2016
    • 负责人:
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    • 依托单位:
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    • 批准号:
      26340027
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2014
    • 负责人:
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    Effects of oral sensation and orexigenic peptide stimulus on sleep and spatial memory
    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2011
    • 负责人:
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    • 依托单位:
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