Study of the effect of rare metals on iNKT cells by molecular nutritional procedure
Study of the effect of rare metals on iNKT cells by molecular nutritional procedure
批准号:
21500789
负责人:
TANAKA Susumu
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
In vitro screening was performed for trace elements and rare metals that influence the enzyme activity of calcineurin(CN), which is involved in cellular immunity. Manganese(Mn^<2+>) noncompetitively inhibited nickel(Ni^<2+>)-stimulated CN activity, and the rare earth lanthanum(La^<3+>) increased CN activity. Next, the influence of vanadium ion(VO)^<3->_4) on the production of interleukin-2(IL-2)(an indicator of cellular immunity) was investigated using the human T-cell line Jurkat cells. This showed that NADPH oxidase-mediated VO^<3->_4induced IL-2 production in Jurkat T-cells.
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マンガンはAP-1を介してホルボールエステルで誘導されたJurkat T細胞のIL-2産生を促進する
锰通过 AP-1 促进佛波酯诱导的 Jurkat T 细胞产生 IL-2
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[田中進, 増田泰紀, 田中佑季, 本間千裕, 高橋克典, 保坂公平, 久保原禅]
通讯作者:
久保原禅
バナジウムはNADPHオキシダーゼを介してJurkat T細胞のIL-2産生を誘導する
钒通过 NADPH 氧化酶诱导 Jurkat T 细胞产生 IL-2
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[田中進, 田中佑季]
通讯作者:
田中佑季
マンガンはニッケル刺激したカルシニューリン活性を不競合的に阻害する
锰非竞争性抑制镍刺激的钙调神经磷酸酶活性
DOI:
--
发表时间:
2009
期刊:
微量栄養素研究
影响因子:
--
作者:
[田中佑季, 大塚恵美子, 保坂公平, 田中進]
通讯作者:
田中進
Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells
锰通过激活 Jurkat T 细胞中的 AP-1 促进佛波酯诱导的白细胞介素 2 的产生
DOI:
10.1016/j.toxlet.2012.04.015
发表时间:
2012
期刊:
Toxicology Letters
影响因子:
3.5
作者:
[Tanaka S, Masuda Y, Honma C, Hosaka K, Takahashi K, & Kubohara Y]
通讯作者:
& Kubohara Y
リコンビナントヒトカルシニューリン活性に対する金属イオンの効果
金属离子对重组人钙调磷酸酶活性的影响
DOI:
--
发表时间:
2011
期刊:
医学と生物学
影响因子:
--
作者:
[田中進, 田中佑季, 伊藤昇, 保坂公平]
通讯作者:
保坂公平
共 6 条
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项目类别:Grant-in-Aid for Scientific Research (C)
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依托单位:
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依托单位:
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Effects of oral sensation and orexigenic peptide stimulus on sleep and spatial memory
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Identification of the transcription factors for hypothalamic orexin
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:TANAKA Susumu
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依托单位:
Transcriptional regulation of orexin by candidate genes for narcolepsy
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资助金额:$2.75万
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依托单位:
Analysis of neural mechanism within brainstem related to the pathogenesis of bruxism and oral dyskinesia.
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资助金额:$3.0万
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依托单位:
Study of the effect of trace elements on cellular immunity by molecular nutritional procedure
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资助金额:$2.5万
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财政年份:2007
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依托单位:
The development and physical properties of two-dimensional Li+ ionic-conductor used rotator phases as matrix
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批准号:19750011
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依托单位:
COMPARATIVE STUDIES ON THE DESTRIBUTION AND BIOLOGY OF CLADOCERA OCCURRING ON THE LITTORAL ZONE OF LAKES IN JAPAN
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负责人:TANAKA Susumu
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依托单位:
海外基金