Molecular diagnosis and carcinogenetic risk evaluation for lung cancer using methylation-specific DNA microarray
Molecular diagnosis and carcinogenetic risk evaluation for lung cancer using methylation-specific DNA microarray
批准号:
20790978
负责人:
ENDO Makoto
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
我们研制了一种纤维型DNA微阵列,在其上固定了甲基化序列探针,并利用该微阵列定量分析了CpG岛4个癌相关基因的DNA甲基化率,复发组RUNX3的甲基化率显著高于存活组。DNA微阵列技术检测肺癌组织中DNA甲基化状态可能成为肺癌复发风险评估的一种新方法。
英文摘要
We devloped a fiber-type DNA microarray on which methylated sequence probes were mounted, and quantitatively analyzed DNA methylation rates (MRs) of 4 cancer-related genes of CpG island using it. In recurrent group rates of methylated RUNX3 was significantly higher than survivor. Analysis of DNA methylation status using DNA microarray could be a promising method for risk assessment in the recurrence of lung cancer.
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Effect of bisphosphonate on tooth replantation.
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Searching of essential nutrients for fish using the self-feeding device in the fish feed from vegetable ingredients
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Immunotoxicological assay using fish neutrophil and toxic effects of the water pollutants
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Molecular Basis of the Two Kinds of Opening Mode of Ryanodine Receptor / Calcium Relase Channel of the Sarcoplasmic Reticulum of Skeletal Muscle
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Development of Human-Centered Support System on Ship Handling for Effective Human Error Prevention
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$7.68万
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财政年份:1998
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负责人:ENDO Makoto
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依托单位:
Isolation of fish macrophage and its physiology
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批准号:09660207
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项目类别:Grant-in-Aid for Scientific Research (C)
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Reinvestigation of calcium release mechanism from the sarcoplasmic reticulum in cardiac excitation-contraction coupling.
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Effect of ammonia to fish neutrophils and its permissible level
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资助金额:$1.22万
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财政年份:1995
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负责人:ENDO Makoto
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依托单位:
Functions of the two types of calcium release channels in the sarcoplasmic reticulum of skeletal muscle.
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批准号:07457023
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.78万
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财政年份:1995
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依托单位:
Modeling Human Errors on Shiphandling -Workload and Performance-
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批准号:07458079
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财政年份:1995
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依托单位:
Causes, Incidence Probability and Safety Rating of Human Error in Ship Operation
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批准号:05452367
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资助金额:$1.92万
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依托单位:
Molecular mechanism of skeletal muscle excitation-contraction coupling
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批准号:03404019
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$14.85万
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财政年份:1991
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负责人:ENDO Makoto
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依托单位:
A physiological and pharmacological study of excitation-contraction coupling by using single skeletal muscle fibres whose intracellular medium can be exchanged.
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批准号:60480125
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.56万
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财政年份:1985
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负责人:ENDO Makoto
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依托单位:
国内基金
海外基金
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