Expression and role of Cytochrome P450 2A6 in colorectal cancer

细胞色素P450（Cytochrome P450）是一种I相酶，在体内大量存在。在结直肠癌（CRC）中，β-内酰胺酶在致癌物和抗肿瘤药物的代谢中起重要作用。有研究表明，大肠癌的发生与大肠癌的发生有关，而大肠癌的发生与大肠癌的发生有关。在此之前，我们已经报道了CYP2A6在结直肠腺癌和腺瘤中的表达。在溃疡性结肠炎中，CYP2A6在再生粘膜中表达。此外，成纤维细胞生长因子2IIIc（FGFR2IIIc）在结直肠腺癌中的过度表达，FGFR2IIIc在结直肠癌的发生和发展中具有重要作用。本研究有可能导致CRC新治疗策略的发展。

Cytochrome P450 (CYP) is one of the phase I enzymes and is found abundantly in the body. In colorectal carcinomas (CRC), CYP has important roles in the metabolisms of carcinogens and anti-tumor drugs. It has been reported that the expression and gene polymorphisms of CYP correlate with a risk of CRC. Previously, we have reported the expression of CYP2A6 in colorectal adenocarcinomas and adenomas. In ulcerative colitis, CYP2A6 was expressed in the regenerative mucosa. Furthermore, overexpression of fibroblast growth factor 2IIIc (FGFR2IIIc) was observed in colorectal adenocarcinomas, and FGFR2IIIc has important roles in carcinogenesis and the progression of CRC. There is a possibility that the present study will lead to the development of new therapeutic strategies for CRC.