Expression and role of Cytochrome P450 2A6 in colorectal cancer

细胞色素P450 2A6在结直肠癌中的表达及作用

• 批准号: 20790976
• 负责人: MATSUDA Yoko
• 金额: $ 2.58万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790976/
• 关键词: Cytochrome P450; 大腸癌; 線維芽細胞増殖因子受容体; 抗癌剤

Cytochrome P450 (CYP) is one of the phase I enzymes and is found abundantly in the body. In colorectal carcinomas (CRC), CYP has important roles in the metabolisms of carcinogens and anti-tumor drugs. It has been reported that the expression and gene polymorphisms of CYP correlate with a risk of CRC. Previously, we have reported the expression of CYP2A6 in colorectal adenocarcinomas and adenomas. In ulcerative colitis, CYP2A6 was expressed in the regenerative mucosa. Furthermore, overexpression of fibroblast growth factor 2IIIc (FGFR2IIIc) was observed in colorectal adenocarcinomas, and FGFR2IIIc has important roles in carcinogenesis and the progression of CRC. There is a possibility that the present study will lead to the development of new therapeutic strategies for CRC.

细胞色素P450（Cytochrome P450）是一种I相酶，在体内大量存在。在结直肠癌（CRC）中，β-内酰胺酶在致癌物和抗肿瘤药物的代谢中起重要作用。有研究表明，大肠癌的发生与大肠癌的发生有关，而大肠癌的发生与大肠癌的发生有关。在此之前，我们已经报道了CYP 2A 6在结直肠腺癌和腺瘤中的表达。在溃疡性结肠炎中，CYP 2A 6在再生粘膜中表达。此外，成纤维细胞生长因子2 IIIc（FGFR 2 IIIc）在结直肠腺癌中的过度表达，FGFR 2 IIIc在结直肠癌的发生和发展中具有重要作用。本研究有可能导致CRC新治疗策略的发展。

项目成果

Lumican in lung cancer cells and stromal tissues, and its clinicopathological significance

Lumican在肺癌细胞和间质组织中的表达及其临床病理意义

• 发表时间: 2008
• 作者: Matsuda Y;et.al.
• 通讯作者: et.al.

Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells

• DOI: 10.1016/j.yexmp.2010.01.010
• 发表时间: 2010-06-01
• 期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY
• 影响因子: 3.6
• 作者: Ishiwata, Toshiyuki;Yamamoto, Tetsushi;Naito, Zenya
• 通讯作者: Naito, Zenya

Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture

• DOI: 10.1007/s00795-010-0497-0
• 发表时间: 2010-12-01
• 期刊: MEDICAL MOLECULAR MORPHOLOGY
• 影响因子: 1.8
• 作者: Matsuda, Yoko;Ishiwata, Toshiyuki;Naito, Zenya
• 通讯作者: Naito, Zenya

Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma

• DOI: 10.3892/ijo_00000107
• 发表时间: 2008-12-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Matsuda, Yoko;Yamamoto, Tetsushi;Naito, Zenya
• 通讯作者: Naito, Zenya

Fibroblast growth factor receptor 2 IIIc development of colorectal adenocarcinoma.

成纤维细胞生长因子受体2 IIIc 结直肠腺癌的发展。

• 发表时间: 2009
• 作者: Matsuda Y;et al.
• 通讯作者: et al.