Pathophysiological research of AGEs-RAGE system and Fetuin-A on bone metabolism and arteriosclerosis
Pathophysiological research of AGEs-RAGE system and Fetuin-A on bone metabolism and arteriosclerosis
批准号:
20791039
负责人:
YAMAMOTO Masahiro
金额:
$2.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Type 2 diabetes is independent risk factor of vertebral fracture. These fractures are not predicted by bone mineral density, indicating that patients with type 2 diabetes have poor bone quality. Vertebral fractures risk is associated with increased serum level of advanced glycation end-products (AGEs) or with relatively insufficient amount of endogenous secretory receptor for AGEs (esRAGE). These results suggest that AGEs-RAGE system affect bone quality. On the other hand, intima media thickness of internal carotid artery, which is one of index of arteriosclerosis, is related with vertebral fractures, suggesting that vertebral fractures and atherosclerosis have common pathologic condition.
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DOI:
10.1007/s00223-009-9272-4
发表时间:
2009-09-01
期刊:
CALCIFIED TISSUE INTERNATIONAL
影响因子:
4.2
作者:
[Kanazawa, Ippei, Yamaguchi, Toru, Sugimoto, Toshitsugu]
通讯作者:
Sugimoto, Toshitsugu
連載EBM講座2型糖尿病患者は骨折しやすいか.
系列循证医学课程:2型糖尿病患者是否更容易发生骨折?
DOI:
--
发表时间:
2009
期刊:
骨粗鬆症治療 8
影响因子:
--
作者:
[山本昌弘、(, 他1名)]
通讯作者:
他1名)
Bone fragility in male glucocorticoid-indubed osteoporosis is not defined by bone mineral density
男性糖皮质激素引起的骨质疏松症的骨脆性不是由骨矿物质密度定义的
DOI:
--
发表时间:
2009
期刊:
Osteoporos Int (印刷中)
影响因子:
--
作者:
[Yamamoto M, 小川 拓哉, Takase H, Anton Bahtiar, Kanazawa I, Kanazawa I, 山本昌弘, 金沢一平, 山本昌弘, 山本昌弘, 山本昌弘, Hayashi K, Kanazawa I, Kanazawa I, Hayashi K]
通讯作者:
Hayashi K
Serum pentosidine level is positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes.
血清戊糖素水平与绝经后 2 型糖尿病女性椎骨骨折的发生呈正相关。
DOI:
--
发表时间:
2008
期刊:
J Clin Endocrinol Metab 93
影响因子:
--
作者:
[Yamamoto M, (他4名)]
通讯作者:
(他4名)
男性ステロイド性骨粗鬆症における腰椎・大腿骨頸部・橈骨骨密度での椎体骨折閾値の検討.
根据类固醇引起的骨质疏松症男性的腰椎、股骨颈和桡骨骨密度检查椎骨骨折阈值。
DOI:
--
发表时间:
2008
期刊:
Osteoporosis Japan 16
影响因子:
--
作者:
[山本昌弘, (2番目他5名)]
通讯作者:
(2番目他5名)
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Elucidation of novel innate immune system by analysis of host-parasite interaction
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Linkage between receptor for advanced glycation end-product
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Building Multidimensional Corporate Appraisal Models on the Basis of Financial Gatekeepers: A US-Japanese Comparison
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Mathematics of inverse problems and practical solution methods
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Role of a nuclear protein IκBζ in innate immunity
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Basic study of low emittance DC electron gun
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Proteins for oxidation of elemental sulfur from a sulfur-oxidizing bacterium in deep-sea hydrothermal fields
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Analysis of the mechanisms for innate immune responses to microbes
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Stability of solution and reconstruction in inverse problems
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Sulfur isotope geochemistry of Besshi-type deposits
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