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Role of a nuclear protein IκBζ in innate immunity

Role of a nuclear protein IκBζ in innate immunity
核蛋白 IκB z 在先天免疫中的作用
批准号:
21790467
负责人:
YAMAMOTO Masahiro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

项目摘要

项目成果

YAMAMOTO Masahiro的其他基金

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中文摘要
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英文摘要
We clarified that an nuclear IκB family protein IκBζ is a master transcriptional factor for the generation of mouse Th17 cells. Ectopic co-expression of IκBζ and RORγt strongly induced Th17 differentiation even in the absence of IL-6 and TGF-β. In addition, IκBζ-deficient mice showed defective Th17 differentiation in vivo and resistance to EAE induction. Moreover, IκBζ in collaboration with RORγt directly associated with the promoter of IL17a and highly induced expression of IL17a.
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DOI: 10.1084/jem.20091703
发表时间: 2009-11-23
期刊: The Journal of experimental medicine
影响因子: --
作者: [Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K]
通讯作者: Takeda K
NFATcl mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
NFATcl 在克氏锥虫感染期间介导 Toll 样受体独立​​的先天免疫反应。
DOI: --
发表时间: 2009
期刊: PLoS Pathog. 5
影响因子: --
作者: [Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K.]
通讯作者: Takeda K.
A single polymorphic amino substitution on Toxoplasma gondii kinase ROP16 detemines the direct and strain-specific activation of Stat3.
弓形虫激酶 ROP16 上的单个多态性氨基取代决定了 Stat3 的直接和菌株特异性激活。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yamamoto M, Soldati-Favre D, Takeda K., Yamamoto M.]
通讯作者: Yamamoto M.
Essential role of ROP16 in the strain-specific and direct activation of Stat3 and Stat6
ROP16 在 Stat3 和 Stat6 菌株特异性和直接激活中的重要作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Yamamoto M, et al., 山本雅裕, 山本雅裕, Masahiro Yamamoto]
通讯作者: Masahiro Yamamoto
12
    An analisys on the division of roles between substantive and "procedural" review of the legislative discretion.
    Pathogenic and genetic analysis of Toxoplasma by Japan, China and South Korea
    • 批准号:
      18KK0226
    • 项目类别:
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • 资助金额:
      $11.48万
    • 财政年份:
      2018
    • 负责人:
      YAMAMOTO Masahiro
    • 依托单位:
    A Study in the Organizational Process of Capital Investment and M&A
    • 批准号:
      17K04074
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2017
    • 负责人:
      YAMAMOTO Masahiro
    • 依托单位:
    Reproduction of prebiotic metabolic pathways with deep-sea hydrothermal electricity