Role of a nuclear protein IκBζ in innate immunity
Role of a nuclear protein IκBζ in innate immunity
批准号:
21790467
负责人:
YAMAMOTO Masahiro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
点击翻译按钮获取中文摘要
英文摘要
We clarified that an nuclear IκB family protein IκBζ is a master transcriptional factor for the generation of mouse Th17 cells. Ectopic co-expression of IκBζ and RORγt strongly induced Th17 differentiation even in the absence of IL-6 and TGF-β. In addition, IκBζ-deficient mice showed defective Th17 differentiation in vivo and resistance to EAE induction. Moreover, IκBζ in collaboration with RORγt directly associated with the promoter of IL17a and highly induced expression of IL17a.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1084/jem.20091703
发表时间:
2009-11-23
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
[Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K]
通讯作者:
Takeda K
NFATcl mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
NFATcl 在克氏锥虫感染期间介导 Toll 样受体独立的先天免疫反应。
DOI:
--
发表时间:
2009
期刊:
PLoS Pathog. 5
影响因子:
--
作者:
[Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K.]
通讯作者:
Takeda K.
A single polymorphic amino substitution on Toxoplasma gondii kinase ROP16 detemines the direct and strain-specific activation of Stat3.
弓形虫激酶 ROP16 上的单个多态性氨基取代决定了 Stat3 的直接和菌株特异性激活。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yamamoto M, Soldati-Favre D, Takeda K., Yamamoto M.]
通讯作者:
Yamamoto M.
Essential role of ROP16 in the strain-specific and direct activation of Stat3 and Stat6
ROP16 在 Stat3 和 Stat6 菌株特异性和直接激活中的重要作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamamoto M, et al., 山本雅裕, 山本雅裕, Masahiro Yamamoto]
通讯作者:
Masahiro Yamamoto
DOI:
10.1126/scisignal.2000387
发表时间:
2009-10-20
期刊:
SCIENCE SIGNALING
影响因子:
7.3
作者:
[Yamazaki, Kohsuke, Gohda, Jin, Inoue, Jun-Ichiro]
通讯作者:
Inoue, Jun-Ichiro
共 12 条
An analisys on the division of roles between substantive and "procedural" review of the legislative discretion.
-
批准号:18K12633
-
项目类别:Grant-in-Aid for Early-Career Scientists
-
资助金额:$1.58万
-
财政年份:2018
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Pathogenic and genetic analysis of Toxoplasma by Japan, China and South Korea
-
批准号:18KK0226
-
项目类别:Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
-
资助金额:$11.48万
-
财政年份:2018
-
负责人:YAMAMOTO Masahiro
-
依托单位:
A Study in the Organizational Process of Capital Investment and M&A
-
批准号:17K04074
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2017
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Reproduction of prebiotic metabolic pathways with deep-sea hydrothermal electricity
-
批准号:16K05625
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2016
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Basic research on vacuum gap insulation for ultra-high voltage devices
-
批准号:16K05385
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2016
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Deep-sea hydrothermal electricity elucidates origin of life: Proposal of Electro-Iron-Sulfur World theory
-
批准号:26610188
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2014
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Development of the in vitro maintenance system for undifferentiated stem cells using Toxoplasma ROP16
-
批准号:25670201
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:YAMAMOTO Masahiro
-
依托单位:
'Environmental Electric Ecosystem', a novel biomass production system
-
批准号:23760797
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2011
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Mathematical studies for diffusion of contaminants
-
批准号:23654030
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2011
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Elucidation of novel innate immune system by analysis of host-parasite interaction
-
批准号:23689029
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$17.56万
-
财政年份:2011
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Linkage between receptor for advanced glycation end-product
-
批准号:22791383
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.25万
-
财政年份:2010
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Building Multidimensional Corporate Appraisal Models on the Basis of Financial Gatekeepers: A US-Japanese Comparison
-
批准号:22530379
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2010
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Mathematics of inverse problems and practical solution methods
-
批准号:21340021
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.82万
-
财政年份:2009
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Basic study of low emittance DC electron gun
-
批准号:20740129
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.33万
-
财政年份:2008
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Pathophysiological research of AGEs-RAGE system and Fetuin-A on bone metabolism and arteriosclerosis
-
批准号:20791039
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.0万
-
财政年份:2008
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Proteins for oxidation of elemental sulfur from a sulfur-oxidizing bacterium in deep-sea hydrothermal fields
-
批准号:19870039
-
项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$1.93万
-
财政年份:2007
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Analysis of the mechanisms for innate immune responses to microbes
-
批准号:19790357
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.36万
-
财政年份:2007
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Mathematical analysis for inverse problems in mathematical scienes and establishment of numerical methods
-
批准号:15340027
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.9万
-
财政年份:2003
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Stability of solution and reconstruction in inverse problems
-
批准号:11440025
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.55万
-
财政年份:1999
-
负责人:YAMAMOTO Masahiro
-
依托单位:
Sulfur isotope geochemistry of Besshi-type deposits
-
批准号:08640610
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1996
-
负责人:YAMAMOTO Masahiro
-
依托单位: