Establishment of cell therapy for transplanting neural crest-derived stem cells into spinal cord injury model of rodent and mammalian

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Neural crest-derived stem cells (NCSCs) are isolated from adult skin and bone marrow, and they have the ability to differentiate into neural cells. Therefore, NCSCs are expected as cell sources for transplantation into spinal cord injury. In our study, we transplanted NCSCs into spinal cord injury model of mice. We observed the transplanted NCSCs surviving in the injured spinal cord, differentiating into neural cells. Moreover, the transplanted NCSCs had no tumorigenesis, suggesting that transplantation of NCSCs are safe. We also isolated and characterized NCSCs from adult marmoset or human skin.