The activation mechanisms of mechanosensitive cation channels in boneremodeling.
The activation mechanisms of mechanosensitive cation channels in boneremodeling.
批准号:
20791349
负责人:
YOSHIDA Takashi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Mechanical stress plays a vital role in maintaining bone architecture. The process by which osteoblasts convert mechanical signal into biochemical responses leading to bone remodeling is not fully understood. In spite of the significant role of channels in osteoblast, the molecular identity of mechanosensitive channels remains unknown. To identify the mechanosensitive channels, we examined the expression level of channels in the clonal mouse osteoblast cell line MC3T3-E1. RT-PCR analysis revealed some mechanosensitive channel genes are expressed in MC3T3-E1 cells.
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感覚センサーとして機能するイオンチャネルの探求
探索充当感觉传感器的离子通道
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[若森実, 吉田卓史, 吉田卓史]
通讯作者:
吉田卓史
TRPC5チャネルの新規活性化機構と生理的意義
TRPC5通道的新颖激活机制及生理意义
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[吉田卓史, 森泰生]
通讯作者:
森泰生
Expression patterns of mechanosensitive TRP channels in osteoblasts.
成骨细胞中机械敏感 TRP 通道的表达模式。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takashi Yoshida, Yuki Miyajima, Minoru Wakamori.]
通讯作者:
Minoru Wakamori.
TRP CHANNELS PLAY A ROLE IN MECHANICAL RESPONSES IN STRETCHED OSTEOBLASTS.
TRP 通道在拉伸的成骨细胞的机械反应中发挥作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takashi Yoshida, Yuki Miyajima, Minoru Wakamori.]
通讯作者:
Minoru Wakamori.
マウス骨芽細胞株MC3T3-E1におけるTRPメカノセンサーチャネルの発現解析
小鼠成骨细胞系 MC3T3-E1 中 TRP 机械传感器通道的表达分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[吉田卓史, 宮島悠旗, 若森実]
通讯作者:
若森実
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