Identification of mechanosensitive channels responded to hypo-osmotic stress in the osteoblast
Identification of mechanosensitive channels responded to hypo-osmotic stress in the osteoblast
批准号:
22791785
负责人:
YOSHIDA Takashi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Mechanical stress plays a vital role in maintaining bone architecture. The process by which osteoblasts convert mechanical signal into biochemical responses leading to bone remodeling is not fully understood. In spite of the significant role of mechanosensitive channels in osteoblast, the molecular identity of mechanosensitive channels remains unknown. When we applied the hypo-osmotic stress in the presence of extracellular Ca^(2+), some cells were responded. But specific TRPV2 or TRPV4 siRNA could not inhibit Ca^(2+)response by hypo-osmotic stress. These results indicate that TRPV2 or TRPV4 channels are not candidate for the hypo-osmotic stress responding channel in osteoblast.
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マウス骨芽細胞MC3T3-E1において剪断応力を受容するTRPチャネル
小鼠成骨细胞MC3T3-E1中接受剪切应力的TRP通道
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[吉田卓史, 若森実]
通讯作者:
若森実
細胞外環境を感知するセンサータンパク質
感知细胞外环境的传感器蛋白
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[近藤大祐, 吉田卓史, 菊地尚, 小松正志, 若森実, Takashi Yoshida, Takashi Yoshida, 吉田卓史]
通讯作者:
吉田卓史
DOI:
10.1523/jneurosci.3360-09.2010
发表时间:
2010-04-21
期刊:
JOURNAL OF NEUROSCIENCE
影响因子:
5.3
作者:
[Mashimo, Tomoji, Ohmori, Iori, Serikawa, Tadao]
通讯作者:
Serikawa, Tadao
骨組織における圧力受容機構の解明
阐明骨组织中的压力感受器机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[吉田卓史, 菊地尚, 高橋かおり, 若森実, 吉田卓史]
通讯作者:
吉田卓史
Mechanosensitive channels in the clonal mouse osteoblast cell line MC3T3-E1
克隆小鼠成骨细胞系 MC3T3-E1 中的机械敏感通道
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takashi Yoshida, Minoru Wakamori]
通讯作者:
Minoru Wakamori
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