lnvolvement of non-coding gene U50HG and U50 snoRNA in lymphatic system

为了阐明U50 snoRNA的未知功能，我们生成了一个mu50缺陷小鼠系。在该小鼠品系中，随着mU50表达的减少，rRNA上靶向mU50的甲基化也减少了。缺乏mu50的小鼠在视觉上与野生型小鼠难以区分，但其中一些动物容易出现淋巴器官缺陷。关于U50在造血谱系中的强表达，启动子分析显示c-MYC和BCL6参与了宿主基因的转录。

To elucidate the not-yet-known function of U50 snoRNA we generated an mU50-deficient mouse line. In this mouse line, mU50-targeted methylations on the rRNA were reduced as with the reduction of mU50 expression. The mU50-deficient mice were indistinguishable from wild-type littermates at sight, but some of those animals were prone to have defects in lymphatic organs. Regarding to the strong U50 expression in hematopoietic lineages, promoter analyses revealed the involvement of c-MYC and BCL6 in the transcription of the host-gene.