Development of odontogenic regenerative therapy by epithelial-mesenchymal interactions using ameloblast and odontoblast-lineage cell lines.

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We try to develop the original tooth regenerative therapy by epithelial-mesenchymal interactions in vitro and in vivo using ameloblast, odontoblast-lineage cell line and scaffold which specialized in the tooth regenerative therapy.In this study, after sub-cutaneous implantation of ameloblast-lineage cell line that cultured three-dimensional in matrigel to athymic nude mice, we ectopically observed enamel epithelium like structure formation and hard tissue construction. We believed that these cell lines are useful tool for clinical tissue engineering technology to repair the tooth