The effect of manners of administration and timing of sevoflurane on myocardial ischemia/reperfusion injury.

2008年：We compared 3.9% sevoflurane exposure groups in six different manners of administration withcontrol group. There were no significant differences in arrhythmias during myocardial durationischemia and reperfusion and I/R (infarct size /area at risk) among seven groups.虽然我们measured 8-OHdG in the blood，【2009】we compared continuous sevoflurane exposure groups in four differentconcentrations (0.5%, 1.0%, 1.5%，2. I/R (infarct size /area at risk) was reduced in a1.0% sevoflurane exposure group. 1.0% continuous sevoflurane exposure depressed production of8-OHdG。

【2008】We compared 3.9% sevoflurane exposure groups in six different manners of administration with control group. There were no significant differences in duration of arrhythmias during myocardial ischemia and reperfusion and I/R (infarct size /area at risk) among seven groups. Although we measured 8-OHdG・in the blood, we could not detect it.【2009】We compared continuous sevoflurane exposure groups in four different concentrations (0.5 %, 1.0%, 1.5%, 2.0%) under k/x anesthesia with control group. I/R (infarct size /area at risk) was reduced in a 1.0% sevoflurane exposure group. 1.0% continuous sevoflurane exposure depressed production of 8-OHdG^・.