Effect of cytokine for integration after bone graft in rat with palatal cleft

细胞因子对腭裂大鼠植骨后整合的影响

• 批准号: 20791604
• 负责人: HATA Yuichiro
• 金额: $ 2.41万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791604/
• 关键词: BMP; 骨移植; 創傷治癒; 口蓋裂; フィブリン糊

The purpose of this study is to clarify the effect of BMP and bFGF on integration of bone graft. 40 days Wistar rat was used for the making the rat palatal loss model, and establishment of the quantitative evaluation method of the bone graft. As a result, the rat palatal loss model's making was established. The palatal bone was drilled by a round bar of 1mm in the diameter. For the method of bone graft, the bone deleted in a round bar was gathered, it mixed with a fibrin paste, and it transplanted to the bone loss part.For the effect of the cytokine of the grafted bone, the results suggested that BMP2 showed an excellent result in the integration and bone growth qualitatively. It will be necessary to examine the establishment of quantification and the effect of bFGF in the future.

本研究的目的是阐明BMP和bFGF对骨移植物整合的影响。采用40日龄Wistar大鼠制作大鼠腭骨缺损模型，建立骨移植的定量评价方法。建立了大鼠腭缺失模型。用直径为1 mm的圆棒在腭骨上钻孔。骨移植方法：取去骨块，制成圆棒状，与纤维蛋白糊混合，移植到骨缺损部位;细胞因子对移植骨的影响：BMP 2在骨整合和骨生长方面表现出良好的效果。今后有必要研究定量的建立和bFGF的作用。