Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease
Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease
批准号:
20800066
负责人:
WATANABE Takuya
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (Start-up)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
This study aimed to develop new therapy for prion diease without side effects, using a complex of siRNA and RVG-9R. The siRNA decreased expression of prion mRNA and prion protein of scrapie form (PrP^<Sc>). And siRNA/RVG-9R complex bound to cell. However, treatment of siRNA/RVG-9R complex did not affect PrP^<Sc> level in prion-infected cell culture. Sequence of RVG-9R needs to optimize for knock-down of prion.
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DOI:
10.1007/s10571-009-9446-7
发表时间:
2010-03-01
期刊:
CELLULAR AND MOLECULAR NEUROBIOLOGY
影响因子:
4
作者:
[Sumi, Noriko, Nishioku, Tsuyoshi, Kataoka, Yasufumi]
通讯作者:
Kataoka, Yasufumi
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依托单位:
海外基金