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Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease

Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease
通过血脑屏障转运将 siRNA 递送至中枢神经系统:朊病毒病的治疗
批准号:
20800066
负责人:
WATANABE Takuya
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (Start-up)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
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中文摘要
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英文摘要
This study aimed to develop new therapy for prion diease without side effects, using a complex of siRNA and RVG-9R. The siRNA decreased expression of prion mRNA and prion protein of scrapie form (PrP^<Sc>). And siRNA/RVG-9R complex bound to cell. However, treatment of siRNA/RVG-9R complex did not affect PrP^<Sc> level in prion-infected cell culture. Sequence of RVG-9R needs to optimize for knock-down of prion.
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DOI: 10.1007/s10571-009-9446-7
发表时间: 2010-03-01
期刊: CELLULAR AND MOLECULAR NEUROBIOLOGY
影响因子: 4
作者: [Sumi, Noriko, Nishioku, Tsuyoshi, Kataoka, Yasufumi]
通讯作者: Kataoka, Yasufumi
Semiclassical analysis of spectral and scattering problems associated with energy crossings
  • 批准号:
    15K17563
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.5万
  • 财政年份:
    2015
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    24791490
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    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2012
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  • 批准号:
    22740094
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.5万
  • 财政年份:
    2010
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    WATANABE Takuya
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The role of cellular prion protein in blood brain barrier
  • 批准号:
    22790178
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.58万
  • 财政年份:
    2010
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