Therapeutic Strategy of Diabetic Macroangiopathy using the Gut Hormone Incretin
Therapeutic Strategy of Diabetic Macroangiopathy using the Gut Hormone Incretin
批准号:
22590831
负责人:
WATANABE Takuya
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The present study shows that incretin-based therapy using DPP-4 inhibitors and GLP-1 analogs, new treatment of diabetes, exerts anti-atherosclerotic effects, other than glucose lowering effect, leading to the prevention of diabetic macroangiopahy (coronary arterydisease, cerebrovascular disease, and arteriosclerosis obliterans). The pleiotrophic effects are attributed to anti-atherogenesis of GLP-1 and/or GIP on vascular cells, such as endothelial cells, vascular smooth muscle cells, and monocytes/macrophages, via individual receptors followed by cAMP activation.
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Endothelial TGF-β signaling inhibits tumor angiogenesis.
内皮 TGF-β 信号传导抑制肿瘤血管生成。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[渡部 昌, 畠山 鎮次, 日和佐隆樹(発表者),張暁萌,薦田操,瀧口正樹,森雅裕,鵜沢顕之,武藤真弓,桑原聡,竹本稔,小林一貴,横手幸太郎,青墳章代,和田猛,吉川由利子,片山薫,町田利生,土居洋文,工藤孝,中村利華,冨吉郷,新免奈津子,吉田涼,太田優子,黒田英行, Takagi T.]
通讯作者:
Takagi T.
Ezetimibe decreases serum amyloid A levels in HDL3 in hemodialysis patients.
依折麦布可降低血液透析患者血清中 HDL3 淀粉样蛋白 A 的水平。
DOI:
--
发表时间:
2010
期刊:
Clinical Nephrology
影响因子:
1.1
作者:
[Hirano T, Watanabe T, et al.]
通讯作者:
et al.
動脈硬化は生命を脅かす怖い病気~発症メカニズムを知れば予防・治療に役立つ~
动脉硬化是一种威胁生命的可怕疾病~了解发病机制有助于预防和治疗~
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakajima Y, NakamuraY, Tomoyasu M, Deguchi H, Tanita T, Yamauchi K., 渡部琢也]
通讯作者:
渡部琢也
Preventive effects of heregulin-β1, a nerve growth factor, on macrophage foam cell formation and atherosclerosis
神经生长因子调蛋白-β1 对巨噬细胞泡沫细胞形成和动脉粥样硬化的预防作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[渡部琢也、平野勉, 他]
通讯作者:
他
ACAT阻害薬(動脈硬化抑制機序と開発の現状、可能性について)
ACAT抑制剂(抑制动脉硬化的机制、开发现状及可能性)
DOI:
--
发表时间:
2010
期刊:
Mebio
影响因子:
--
作者:
[渡部琢也, 宮崎章]
通讯作者:
宮崎章
共 51 条
Semiclassical analysis of spectral and scattering problems associated with energy crossings
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批准号:15K17563
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2015
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负责人:WATANABE Takuya
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依托单位:
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资助金额:$2.75万
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Research on the problems of merging turning points via the semi-classical and microlocal analysis
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批准号:22740094
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资助金额:$2.5万
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财政年份:2010
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负责人:WATANABE Takuya
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依托单位:
The role of cellular prion protein in blood brain barrier
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批准号:22790178
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:WATANABE Takuya
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依托单位:
Elucidation of the mechanisms regulating bone metastasis and invasion via the interaction between tumor and bone microenvironment.
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批准号:21791381
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:WATANABE Takuya
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依托单位:
Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease
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批准号:20800066
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
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资助金额:$2.11万
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Mechanisms of Macrophage Foam Cell Formation and Hypertensive Complications Caused by Vasoactive Agents
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批准号:18590824
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.46万
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财政年份:2006
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负责人:WATANABE Takuya
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依托单位:
Analysis of transcription factors and of crosstalk between proteinase and extracellular matrix that are related to invasive process of glioblastoma
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批准号:15390431
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2003
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负责人:WATANABE Takuya
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海外基金