Roles of the serotonin synthesis emzyme, TphD2, in body patterning

血清素合成酶 TphD2 在身体模式中的作用

• 批准号: 20870024
• 负责人: MAEGAWA Shingo
• 金额: $ 2.11万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20870024/
• 关键词: 胚葉形成; 原腸形成; 体節形成; 胚発生; セロトニン; 形態形成

I found the following facts with zebrafish embryos. 1. Inhibitors of tryptophan hydroxylase or the antidepressant, Prozac, affected convergence during the body patterning. 2. A serotonin transporter, serta, which is the target for Prozac, is expressed during gastrulation. 3. Gastrula embryos produced serotonin. Based on the findings, I conclude that serotonin is involved in regulation of convergence movements during body patterning.

关于斑马鱼胚胎，我发现了以下事实。1.色氨酸羟化酶抑制剂或抗抑郁药百忧解影响了身体造型过程中的收敛。2.5-羟色胺转运体SERTA是百忧解的靶标，在原肠形成过程中表达。3.胃肠胚胎产生5-羟色胺。根据这些发现，我得出结论，5-羟色胺参与了身体造型过程中收敛运动的调节。

项目成果

Roles of tryptophan hydroxylase in zebrafish embryogenesis.

色氨酸羟化酶在斑马鱼胚胎发生中的作用。

• 发表时间: 2009
• 作者: Shingo Maegawa;Hiroshi Hosokawa;Eric S. Weinberg;Shigeo Kobayahsi
• 通讯作者: Shigeo Kobayahsi

Serotonin in involved in zebrafish body patterning

血清素参与斑马鱼的身体图案

• 发表时间: 2009
• 作者: Shingo Maegawa;Hiroshi Hosokawa;Eric S. Weinberg;Shigeo Kobayahsi
• 通讯作者: Shigeo Kobayahsi

Roles of tryptophan hydroxylase in early development

色氨酸羟化酶在早期发育中的作用

• 发表时间: 2008
• 作者: Shingo Maegawa;Hiroshi Hosokawa;Eric S. Weinberg;Shigeo Kobayashi
• 通讯作者: Shigeo Kobayashi

A novel application of metabolomics in vertebrate development

• DOI: 10.1016/j.bbrc.2009.06.041
• 发表时间: 2009-08-14
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Hayashi, Shunsuke;Akiyama, Shinichi;Fukusaki, Eiichiro
• 通讯作者: Fukusaki, Eiichiro

Roles of Tryptophan Hydroxylase in Early Developmant

色氨酸羟化酶在早期发育中的作用

• 发表时间: 2008
• 作者: 前川真吾;細川浩;Eric S. Weinberg;小林茂夫;前川真吾;前川真吾;前川真吾;前川真吾
• 通讯作者: 前川真吾