Development of Collateral Circulation in the Ischemic Brain

缺血脑中侧支循环的发展

• 批准号: 20590997
• 负责人: KITAGAWA Kazuo
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590997/
• 关键词: 脳虚血; 側副血行; 血管新生; 高血圧; 慢性低潅流; 造血因子; 慢性低灌流; アンジオテンシンII受容体拮抗薬

Enhancing collateral artery growth is a potent therapeutic approach to treat ischemic brain disease from occlusive artery. Brain ischemia was created by occluding left common carotid artery (CCA) in C57/BL6 mice. Following the surgery, G (granulocyte)-CSF (100μg/kg/day) was administered daily for 5 days. G-CSF increased circulating blood monocytes and Mac-2 positive cells in the brain dorsal surface, and promoted leptomeningeal collateral growth. In spontaneously hypertensive rats (SHR), CCA occlusion did not enlarge the leptomeningeal anastomosis in contrast to that in normotensive rats. However, decreasing blood pressure using an angiotensin II AT1 receptor blocker restored the beneficial effect of CCA occlusion on collateral growth. Enhancement or preservation of collateral growth by G-CSF or anti-hypertensive treatment would be a future target for developing a new strategy against ischemic brain disease.

增强侧支动脉生长是治疗动脉闭塞性缺血性脑疾病的有效方法。闭塞左颈总动脉（CCA）引起C57/BL6小鼠脑缺血。术后给予G（粒细胞）-CSF （100μg/kg/天），每日5天。G-CSF增加脑背表面循环血液单核细胞和Mac-2阳性细胞，促进小脑膜侧支生长。在自发性高血压大鼠（SHR）中，与正常大鼠相比，CCA闭塞没有扩大小脑膜吻合。然而，使用血管紧张素II AT1受体阻滞剂降低血压可以恢复CCA闭塞对侧支生长的有益作用。通过G-CSF或抗高血压治疗来增强或保存侧枝生长将是未来开发对抗缺血性脑疾病新策略的目标。

项目成果

Hypertension Impairs Leptomeningeal Collateral Growth After Common Carotid Artery Occlusion: Restoration by Antihypertensive Treatment

• DOI: 10.1002/jnr.22522
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Omura-Matsuoka, Emi;Yagita, Yoshiki;Kitagawa, Kazuo
• 通讯作者: Kitagawa, Kazuo

Granulocyte Colony-Stimulating Factor Enhances Arteriogenesis and Ameliorates Cerebral Damage in a Mouse Model of Ischemic Stroke

• DOI: 10.1161/strokeaha.110.597799
• 发表时间: 2011-03-01
• 期刊: STROKE
• 影响因子: 8.3
• 作者: Sugiyama, Yukio;Yagita, Yoshiki;Kitagawa, Kazuo
• 通讯作者: Kitagawa, Kazuo

Activation of NR2A Receptors Induces Ischemic Tolerance through CREB Signaling

• DOI: 10.1038/jcbfm.2010.18
• 发表时间: 2010-08
• 期刊: Journal of Cerebral Blood Flow & Metabolism
• 影响因子: 6.3
• 作者: Y. Terasaki;Tsutomu Sasaki;Y. Yagita;Shuhei Okazaki;Y. Sugiyama;N. Oyama;E. Omura-Matsuoka;S. Sakoda-S.

教育講演 : 脳虚血耐性現象の分子病態について

教育讲座：脑缺血耐受现象的分子病理学

• 发表时间: 2009
• 作者: Matsui Y;Satoh K;Mutsukura K;Watanabe T;Nishida N;Matsuda H;Sugino M;Shirabe S;Eguchi K;Kataoka Y;北川一夫
• 通讯作者: 北川一夫

Treatment with Angiotensin II AT, Receptor Blocker Recovers Ischemic Tolerance induced by Chronic Hypoperfusion in Focal Cerebral Ischemia Model of Spontaneously Hypertensive Rats

血管紧张素 II AT 受体阻滞剂治疗可恢复自发性高血压大鼠局灶性脑缺血模型中慢性低灌注引起的缺血耐受性

• 发表时间: 2009
• 作者: Emi Omura-Matsuoka;Yoshiki Yagita;Tsutomu Sasaki;Yasukazu Terasaki;Naoki Ohyama;Yukio Sugiyama;Kazuo Kitagawa
• 通讯作者: Kazuo Kitagawa