Development of Collateral Circulation in the Ischemic Brain

增强侧支动脉生长是治疗动脉闭塞性缺血性脑疾病的有效方法。闭塞左颈总动脉（CCA）引起C57/BL6小鼠脑缺血。术后给予G（粒细胞）-CSF （100μg/kg/天），每日5天。G-CSF增加脑背表面循环血液单核细胞和Mac-2阳性细胞，促进小脑膜侧支生长。在自发性高血压大鼠（SHR）中，与正常大鼠相比，CCA闭塞没有扩大小脑膜吻合。然而，使用血管紧张素II AT1受体阻滞剂降低血压可以恢复CCA闭塞对侧支生长的有益作用。通过G-CSF或抗高血压治疗来增强或保存侧枝生长将是未来开发对抗缺血性脑疾病新策略的目标。

Enhancing collateral artery growth is a potent therapeutic approach to treat ischemic brain disease from occlusive artery. Brain ischemia was created by occluding left common carotid artery (CCA) in C57/BL6 mice. Following the surgery, G (granulocyte)-CSF (100μg/kg/day) was administered daily for 5 days. G-CSF increased circulating blood monocytes and Mac-2 positive cells in the brain dorsal surface, and promoted leptomeningeal collateral growth. In spontaneously hypertensive rats (SHR), CCA occlusion did not enlarge the leptomeningeal anastomosis in contrast to that in normotensive rats. However, decreasing blood pressure using an angiotensin II AT1 receptor blocker restored the beneficial effect of CCA occlusion on collateral growth. Enhancement or preservation of collateral growth by G-CSF or anti-hypertensive treatment would be a future target for developing a new strategy against ischemic brain disease.