The neurophysiological study of the association between K+ channel dysfunction and motor neuronal loss in amyotrophic lateral sclerosis

同时观察了小鼠Wallerian变性和再生过程中运动轴突兴奋性和Na+、K+通道在结旁/结旁的表达变化，并报道了它们之间的联系。我们还研究了运动神经元疾病中神经兴奋性的变化及其与疾病病理生理学的关系，并研究了通道病在某些神经系统疾病中的病理生理学作用。研究结果在一些专题讨论会和会议上作了介绍，并在一些论文中发表。

We estimated simultaneously the changes of motor axonal excitability properties and nodal/paranodal ion channel expressions of Na+ and K+ channels in the process of the Wallerian degeneration and regeneration in mice model, and reported the association among them. We also studied the nerve excitability changes in the motor neuron diseases and its associations with the disease pathophysiology, and studied the pathophysiological roles of channelopathy in some neurological disorders. The results were presented in some symposiums and conferences, and were published in some papers.