Relation between motor neuronal cell death and persistant sodium current disturbance in ALS

我们研究了肌萎缩侧索硬化症（ALS）和脊髓延髓肌萎缩症（SBMA）等运动神经元疾病中运动神经轴突兴奋性的变化，并将研究结果作为已发表的文章报道，分析了ALS运动神经轴突兴奋性变化对疾病预后的影响，我们发现运动轴突兴奋性是肌萎缩侧索硬化症患者生存的强有力的预测因素：特别是，我们阐明了轴突持续性钠电流，估计SDTC和潜在的增加，是肌萎缩侧索硬化患者生存期较短的强而独立的预测因子。我们在《神经病学、神经外科学和精神病学杂志》（J Neurol Neurosurg Psychiatry）上发表了这篇论文。2012;83：734-8.）。

We studied the changes of motor nerve axonal excitabilty properties in motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA), and we reported the results of the studies as the published articles.We analyzed the effects of the changes of motor nerve axonal excitability properties in ALS on the disease prognosis, and we found that motor axonal excitability properties were strong predictors for survival in amyotrophic lateral sclerosis: especially, we clarified that axonal persistent sodium currents, estimated by SDTC and latent addition, are strong and independent predictors for shorter survival in patients with ALS. We reported the results as the publised article in Journal of Neurology, Neurosurgery, and Psychiatry (J Neurol Neurosurg Psychiatry. 2012;83:734-8.).