Relation between motor neuronal cell death and persistant sodium current disturbance in ALS

我们研究了肌萎缩性侧索硬化症（ALS）和脊髓和球性肌萎缩症（SBMA）等运动神经元疾病中运动神经轴突兴奋性的变化，并将研究结果作为文章报道。我们分析了ALS患者运动神经轴突兴奋性的变化对疾病预后的影响，发现运动神经轴突兴奋性是肌萎缩侧索硬化症患者生存的有力预测因素：特别是，我们明确了轴突持续钠电流，通过SDTC和潜在附加来估计，是ALS患者较短生存期的强大且独立的预测因素。我们将研究结果发表在Journal of Neurology， Neurosurgery, and Psychiatry （J Neurol neurosurgical Psychiatry. 2012;83:734-8）。

We studied the changes of motor nerve axonal excitabilty properties in motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA), and we reported the results of the studies as the published articles.We analyzed the effects of the changes of motor nerve axonal excitability properties in ALS on the disease prognosis, and we found that motor axonal excitability properties were strong predictors for survival in amyotrophic lateral sclerosis: especially, we clarified that axonal persistent sodium currents, estimated by SDTC and latent addition, are strong and independent predictors for shorter survival in patients with ALS. We reported the results as the publised article in Journal of Neurology, Neurosurgery, and Psychiatry (J Neurol Neurosurg Psychiatry. 2012;83:734-8.).