Growth and differentiation of hematopoietic tumor cells through transcriptional Mediator complex

转录介体复合物，RNA聚合酶II全酶复合物的亚复合物，最终整合许多细胞内信号并将这些信号传递到RNA聚合酶II核心酶复合物。在这项研究中，我们已经表明，介体亚基MED1在恶性，以及正常的造血细胞分化中起着重要的作用，作为核受体和GATA 1的特异性共激活剂，造血的关键激活剂。MED1似乎也促进这些细胞的增殖。我们还提出了这些过程的分子机制。

The transcriptional Mediator complex, subcomplex of the RNA polymerase II holoenzyme complex, ultimately integrates many intracellular signals and conveys these signals to the RNA polymerase II core enzyme complex. In this study, we have shown that the Mediator subunit MED1 plays an important role in malignant, as well as normal, hematopoietic cell differentiation as a specific coactivator for nuclear receptors and GATA1, key activators for hematopoiesis. MED1 appears to promote proliferation of these cells as well. We also propose the molecular mechanisms underlying these processes.