Comprehensive genome analyses of neuroblastoma

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Neuroblastoma is a childhood tumor originating from progenitor cells of the sympathetic nervous system. The tumor displays a broad spectrum of clinical behavior, ranging from spontaneous regression to fatal progression despite intensive therapy. We have been collecting molecular signatures of each tumor subset, such as genomic copy number changes and mRNA expression profiles, to clarify molecular mechanism of oncogenesis and progression of neuroblastoma. In this study, we further conducted the analyses to find epigenetic changes occurred in aggressive neuroblastomas as well as miRNA expression profiling of the tumors.