A research of nutritional strategies to prevent metabolic syndrome in patients with fetal growth restriction

胎儿生长受限患者预防代谢综合征的营养策略研究

• 批准号: 20591296
• 负责人: HAYAKAWA Masahiro
• 金额: $ 2.66万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591296/
• 关键词: 胎児発育不全; 中枢神経障害; 栄養管理; 合成トロンボキサンA2; メタボリック症候群; 中枢神経障

Fetal growth restriction (FGR) is one of the causes of small-for-gestational age (SGA). SGA is high risk of neurological squelae in later life. Neonatologists have introduced aggressive nutrition to SGA infants in order to prevent from neurological sequelae. However, it is suggested that such nutritional strategies might produce metabolic syndrome in later life. In this study, postnatal nutritional intervention might induce metabolic syndrome in later life and alternation of lipid in brain. It is suggested that optimal nutritional strategies might be important in SGA infants in order to decrease morbidity.

胎儿生长受限（FGR）是导致小于胎龄儿（SGA）的原因之一。SGA在以后的生活中有很高的神经性痴呆风险。新生儿学家已经引入积极的营养，以防止从神经系统后遗症的SGA婴儿。然而，这表明，这种营养策略可能会在以后的生活中产生代谢综合征。本研究提示，出生后营养干预可能会导致日后代谢综合征的发生和脑内脂质的改变。建议最佳的营养策略可能是重要的SGA婴儿，以降低发病率。

项目成果

Delayed neurological signs following isolated parasagittal injury in asphyxia at term

• DOI: 10.1016/j.ejpn.2007.10.003
• 发表时间: 2008-09-01
• 期刊: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
• 影响因子: 3.1
• 作者: Sato, Yoshiaki;Hayakawa, Masahiro;Kojima, Seiji
• 通讯作者: Kojima, Seiji

Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS).

日本医院感染监测 (JANIS) 新生儿重症监护病房医院感染的危险因素。

• 发表时间: 2008
• 期刊: Acta Med Okayama. 62(4)
• 作者: Babazono A.;Hayakawa M.;et al.
• 通讯作者: et al.

The Study of Metabolic Syndrome in Iintrauterine Growth Retardation Rats induced by Synthetic Tthromboxane A2

合成血栓A2致宫内生长迟缓大鼠代谢综合征的研究

• 发表时间: 2008
• 作者: Hayakawa;M;et al
• 通讯作者: et al

Risk factors for early death in neonates with Down syndrome and transient leukaemia

• DOI: 10.1111/j.1365-2141.2008.07231.x
• 发表时间: 2008-08-01
• 期刊: BRITISH JOURNAL OF HAEMATOLOGY
• 影响因子: 6.5
• 作者: Muramatsu, Hideki;Kato, Koji;Kojima, Seiji
• 通讯作者: Kojima, Seiji

Prolonged EEG depression in term and near-term infants with hypoxic ischemic encephalopathy and later development of West syndrome

• DOI: 10.1111/j.1528-1167.2010.02727.x
• 发表时间: 2010-12-01
• 期刊: EPILEPSIA
• 影响因子: 5.6
• 作者: Kato, Toru;Okumura, Akihisa;Watanabe, Kazuyoshi
• 通讯作者: Watanabe, Kazuyoshi