Molecular mechanisms of regulatory B cells in immuno-dermatological diseases

调节性 B 细胞在免疫皮肤病中的分子机制

• 批准号: 20591339
• 负责人: FUJIMOTO Manabu
• 金额: $ 3万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591339/
• 关键词: B細胞; 免疫; 皮膚疾患; 皮膚免疫; 自己免疫疾患

Peritoneal B-la cells have been shown to suppress the later phase of contact hypersensitivity reaction. The cell surface expression phenotype of splenic marginal zone regulatory B cells has been clarified. Moreover, the role of regulatory B cells in murine model of systemic lupus erythematosus has been demonstrated.

腹膜B-1a细胞已被证明可以抑制接触性超敏反应的后期。脾边缘区调节性 B 细胞的细胞表面表达表型已被阐明。此外，调节性 B 细胞在系统性红斑狼疮小鼠模型中的作用已得到证实。

项目成果

RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells

• DOI: 10.4049/jimmunol.182.2.957
• 发表时间: 2009-01-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Oda, Hiroyo;Fujimoto, Manabu;Shirai, Mutsunori
• 通讯作者: Shirai, Mutsunori

Regulatory B cells inhibit EAE initiation while other B cells promote disease progression.

调节性 B 细胞抑制 EAE 的发生，而其他 B 细胞则促进疾病进展。

• 发表时间: 2008
• 期刊: J Clin Invest 118
• 作者: Matsushita T;Yanaba K;Bouaziz J-D;Fujimoto M;Tedder TF.
• 通讯作者: Tedder TF.

Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse

• DOI: 10.1136/ard.2007.073387
• 发表时间: 2008-06-01
• 期刊: ANNALS OF THE RHEUMATIC DISEASES
• 影响因子: 27.4
• 作者: Komura, K.;Fujimoto, M.;Sato, S.
• 通讯作者: Sato, S.

Regulatory B cells inhibit EAE initiation while other B cells promote disease progression

调节性 B 细胞抑制 EAE 启动，而其他 B 细胞促进疾病进展

• 发表时间: 2008
• 期刊: J Clin Invest 118
• 作者: Matsushita T;Yanaba K;Bouaziz J D;Fuiimoto M;Tedder TF
• 通讯作者: Tedder TF

Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity.

• DOI: 10.4049/jimmunol.0902385
• 发表时间: 2010-05-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Watanabe R;Ishiura N;Nakashima H;Kuwano Y;Okochi H;Tamaki K;Sato S;Tedder TF;Fujimoto M
• 通讯作者: Fujimoto M