Identification of marker molecules specific for regulatory B cells

近年来，“调节性B细胞”在调节免疫应答中的重要作用得到了广泛的重视。为了进一步阐明调节性B细胞功能的分子机制，鉴定调节性B细胞的特异性标记分子是必要的。在这项研究中，我们试图使用全面的基因表达分析来鉴定这些基因。我们已经确定了大约180个候选基因。我们目前正在研究其中10个候选转录基因的体内和体外功能。

Recently, the important roles of"regulatory B cells"in the regulation of immune responses have been widely appreciated. To further clarify the molecular mechanisms of regulatory B cell functions, identification of marker molecules specific for regulatory B cells is necessary. In this study, we have attempted to identify such genes using comprehensive gene expression analysis. We have identified approximately 180 candidate genes. We are currently studying the in vivo and in vitro functions of 10 candidate transcriptional genes among them.