Molecular mechanisms of regulatory B cell inhibition on skin immunological diseases

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Signal transduction mechanisms responsible for IL-10 production in regulatory B cells were analyzed. BLNK is an important adaptor protein in B cell signal transduction. B cells from BLNK-deficient mice showed diminished IL-10 production in CD1dhiCD5+ B cells. Accordingly, BLNK-deficient mice exhibited augmented contact hypersensitivity response. CD1dhiCD5+ B cells from BLNK-deficient mice showed impaired Stat3 activation, which was dependent on Btk activity. Moreover, exogenous addition of IL-10 in culture markedly increased the number of IL-10-producing B cells, suggesting the presence of positive feedback loop provided by IL-10 stimulation.