Predictors of side effects induced by second generation antipsychotics

1)在接受第二代抗精神病药物治疗的受试者表现出空腹血糖受损之前，脂肪细胞因子的失调可能已经发生。2) 9- oh -利培酮（RIS）在催乳素（PRL）升高中的作用被认为比RIS更重要，且9-OH-RIS对PRL水平的影响存在性别差异。3) RIS组夜间平均QTcF明显长于奥氮平组和对照组。

1) Dysregulation of the adipocytokines may have already occurred before subjects undergoing treatment with second-generation antipsychotic agents exhibit impaired fasting glucose.2) 9-OH-risperidone (RIS) is considered to play a more important role in prolactin (PRL) elevation than RIS, and a gender difference exists in the effect of 9-OH-RIS on PRL level.3) The mean QTcF in the RIS group was significantly longer than that of the olanzapine and control groups during nighttime.