Studies on novel molecular imaging using X-rays
利用 X 射线进行新型分子成像研究
基本信息
- 批准号:20591460
- 负责人:
- 金额:$ 2.58万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2010
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Utilizing cadmium telluride (CdTe) detectors, we developed four-types of energy-discrimination X-ray imaging systems as follows: two transmission-type X-ray cameras (ED-CAM), two reflection-type X-ray fluorescence cameras (XRF-CAM), two energy-discrimination X-ray CT (ED-CT) systems, and two XRF-CT systems. Using ED-CAMs, we performed K-edge imaging using contrast media and suspensions of iodine, cerium, and gadolinium, and spatial resolutions were 0.2×0.2 mm^2. Mapping of iodine, cerium, and gadolinium atoms in cancerous region was carried out by use of XFR-CAMs. K-edge CT for imaging the three atoms was accomplished using ED-CT systems with spatial resolutions of 0.5×0.5 mm^2. Although the skin doses were high using XRF-CT systems, weakly remained iodine atoms in the cancerous region were observed at high contrast. To decrease X-ray exposure time for ED-CT, we developed an oscillation linear CdTe detector, and the scan velocity was increased from 5.0 to 25.0 mm/s. We also developed a 15 Mcps energy-discrimination CT system with a scan velocity of 600 mm/s. Embossed radiography (ER) was carried out using single- or dual-energy subtraction radiography after shifting of the second image, and concavoconvex images such as phase-differential images were obtained. Furthermore, the spatial resolutions were improved to 40×40・m by magnification embossed radiography (MER) using a 100・m-focus X-ray tube.
利用碲化镉(CdTe)探测器,我们开发了四种类型的能量鉴别X射线成像系统如下:两个透射型X射线相机(ED-CAM),两个反射型X射线荧光相机(XRF-CAM),两个能量鉴别X射线CT(ED-CT)系统,和两个XRF-CT系统。使用ED-CAM,我们使用造影剂和碘、铈和钆的悬浮液进行K边缘成像,空间分辨率为0.2×0.2 mm^2。利用XFR-CAM对癌组织中的碘、铈和钆原子进行了定位。利用空间分辨率为0.5×0.5 mm^2的ED-CT系统完成了对三个原子进行K边CT成像。虽然使用XRF-CT系统的皮肤剂量很高,但在高对比度下观察到癌区域中残留的碘原子很弱。为了缩短ED-CT的X射线曝光时间,我们研制了一种振荡式线性CdTe探测器,扫描速度从5.0 mm/s提高到25.0 mm/s。我们还开发了15 Mcps能量鉴别CT系统,扫描速度为600 mm/s。在第二图像移位后,使用单能量或双能量减影摄影进行压印摄影(ER),并获得凹凸图像,如相位微分图像。采用100·m焦点X射线管进行放大浮雕摄影(MER),空间分辨率提高到40×40·m。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Embossed radiography utilizing a subtraction program in conjunction with a 0.5-mm-focus x-ray tube
利用减法程序与 0.5 毫米焦点 X 射线管结合进行浮雕射线照相
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:E. Sato;A. Purkhet;A. Osawa;H. Matsukiyo;T. Enomoto;M. Watanabe;K. Takahashi;S. Sato;A. Ogawa;J. Onagawa
- 通讯作者:J. Onagawa
ZnO rasors using a hydrothermally grown ZnO single crystal
使用水热法生长的 ZnO 单晶的 ZnO 剃刀
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:H. Endo;T. Chiba;K. Meguro;K. Takahashi;M. Fujisawa;S. Sugimura;S. Narita;E. Sato;Y. Kashiwaba
- 通讯作者:Y. Kashiwaba
ZnO radiation sensors using a hydrothermally grown ZnO single crystal
使用水热法生长的 ZnO 单晶的 ZnO 辐射传感器
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:H.Endo;T.Chiba;K.Meguro;K.Takahashi;M.Fujisawa;S.Sugimura;S.Narita;E.Sato;Y.Kashiwaba
- 通讯作者:Y.Kashiwaba
Biomedical embossed radiography utilizing energy subtraction
利用能量减法的生物医学浮雕射线照相
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:E. Sato;A. Osawa;H. Matsukiyo;T. Enomoto;M. Watanabe;J. Nagao;P. Abderyim;E. Tanaka;A. Ogawa;S. Sato
- 通讯作者:S. Sato
Mcps-range Photon-counting X-ray computed tomography system utilizing an LSO-MPPC sensor
采用 LSO-MPPC 传感器的 Mcps 范围光子计数 X 射线计算机断层扫描系统
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:E.Sato;Y.Oda;A.Abudurexiti;O.Hagiwara;A.Osawa H.Matsukiyo;T.Enomoto;M.Watanabe;J.Nagao;S.Sugimura;H.Endo;S.Saito A.Ogawa
- 通讯作者:S.Saito A.Ogawa
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SATO Eiichi其他文献
Three-dimensional internal failure propagation by spherical elastic waves in fused silica glass plate subjected to hypervelocity impact of debris
碎片超高速冲击下熔融石英玻璃板中球面弹性波的三维内部失效传播
- DOI:
10.1299/transjsme.18-00012 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
NAGANO Mikio;KAWAI Nobuaki;HASEGAWA Sunao;KITAZONO Koichi;SATO Eiichi - 通讯作者:
SATO Eiichi
SATO Eiichi的其他文献
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{{ truncateString('SATO Eiichi', 18)}}的其他基金
Remaining life assessment through thermal-fatigue analysis of copper alloy for combustion chamber of reusable rocket engine
可重复使用火箭发动机燃烧室用铜合金的热疲劳分析剩余寿命评估
- 批准号:
23246147 - 财政年份:2011
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of a high-speed energy-dispersive X-ray computed tomography system and its application to molecular-level imaging
高速能量色散X射线计算机断层扫描系统的研制及其在分子水平成像中的应用
- 批准号:
23591791 - 财政年份:2011
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
On families of rational curves and Fano varieties.
关于有理曲线族和 Fano 簇。
- 批准号:
22540050 - 财政年份:2010
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Research on rationally connected varieties
理性关联品种研究
- 批准号:
19540037 - 财政年份:2007
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
In situ immunological analyses of human sporadic carcinomas.
人类散发性癌的原位免疫学分析。
- 批准号:
19790271 - 财政年份:2007
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Study on Dislocation Mechanism of Ambient Temperature Creep in Hexagonal Close-packed Metals and Alloys
六方密排金属及合金环境温度蠕变位错机理研究
- 批准号:
18360342 - 财政年份:2006
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of novel x-ray generators and their applications to monochromatic radiography systems instead of synchrotrons
新型 X 射线发生器的开发及其在单色射线照相系统中替代同步加速器的应用
- 批准号:
16591222 - 财政年份:2004
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Many-sided researches on rationally connected projective varieties-Fano varieties are unirational ?
有理关联射影簇的多方研究——法诺簇是非有理的?
- 批准号:
14340014 - 财政年份:2002
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Experimental Verification of Homogeneous/ Heterogeneous Deformation in High Temperature Creep of Inclusion Bearing Material
夹杂轴承材料高温蠕变均匀/非均匀变形的实验验证
- 批准号:
14350374 - 财政年份:2002
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of high-dose-rate quasi-x-ray laser generators and applications to medical radiographies including polycapillary radiography
高剂量率准 X 射线激光发生器的开发及其在医学放射成像(包括多毛细管放射成像)中的应用
- 批准号:
12670902 - 财政年份:2000
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)














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