Development of a high-speed energy-dispersive X-ray computed tomography system and its application to molecular-level imaging

高速能量色散X射线计算机断层扫描系统的研制及其在分子水平成像中的应用

• 批准号: 23591791
• 负责人: SATO Eiichi
• 金额: $ 3.24万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591791/
• 关键词: Ｘ線CT; エネルギー弁別CT; 高速CdTe検出器; LSO-MPPC検出器; YAP(Ce)-MPPC検出器; ヨウ素KエッジCT; ガドリニウムKエッジCT; エネルギーサブトラクション; フォトンカウンティングCT; 高速エネルギー弁別; CdTe検出器; 高速デュアルエネルギーCT; エネルギー弁別X線CT; Si-PIN検出器; 電荷有感式増幅器; コンパレーター; K-エッジCT; 分子イメージング; X線CTシステム; エネルギー弁別; フォトンカウ

In the present research, we developed an energy-dispersive X-ray computed tomography (ED-CT) system using a 25 mm/s linear CdTe scanner, a turntable, and an X-ray generator. Using this ED-CT with a maximum count rate of sub-Mcps, we performed enhanced K-edge imaging using iodine and gadolinium contrast media, and blood vessels and cancerous regions were observed at high contrast. Using the CdTe detector in conjunction with an x-y stage, we also developed a transmission-type camera, a reflection-type fluorescence camera, and a back-scattering X-ray camera. To carry out Mcps-range imaging, we developed LSO-MPPC and YAP(Ce)-MPPC detectors. Using these two detectors, we constructed the ED-CT system and performed high-speed K-edge imaging. Lately, a dual-energy comparator device was developed, and dual-energy subtraction was performed using two different energy images which were obtained simultaneously.

在本研究中，我们开发了一个能量色散X射线计算机断层扫描（ED-CT）系统，使用25 mm/s的线性CdTe扫描仪，转台，和X射线发生器。使用这种ED-CT，最大计数率为sub-Mcps，我们使用碘和钆造影剂进行了增强K边缘成像，并在高对比度下观察了血管和癌性区域。使用碲化镉探测器结合的x-y阶段，我们还开发了一个传输型相机，反射型荧光相机，和背散射X射线相机。为了实现Mcps距离成像，我们研制了LSO-MPPC和雅普（Ce）-MPPC探测器。使用这两个探测器，我们构建了ED-CT系统，并进行高速K边缘成像。最近，开发了一种双能量比较装置，并使用同时获得的两种不同能量图像进行双能量减影。