Development of the device of real-time direct measurement of spinal cord blood flow at the site of compression

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We were able to observe real-time blood flow at the site of compression and to obtain the critical compression force (20g) for a rat spinal cord injury model using a novel device to measure blood flow. We found that 20 minutes of ischemia/compression periods induces reversible hindlimb motor function damage. However, 40 minutes of that produces irreversible paralysis. The mechanisms of the damage include inflammation induced by proliferated and activated microglia, apoptosis in neuron and oligodendrocyte and blood-spinal cord barrier damage.