Development of the device of real-time direct measurement of spinal cord blood flow at the site of compression

实时直接测量压迫部位脊髓血流量装置的研制

• 批准号: 20591744
• 负责人: MORINO Tadao
• 金额: $ 1.83万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591744/
• 关键词: 脊髄損傷; 脊髄虚血; 脊髄血流測定; マイクログリア; apoptosis; 血液脊髄関門; 虚血; 血流測定

We were able to observe real-time blood flow at the site of compression and to obtain the critical compression force (20g) for a rat spinal cord injury model using a novel device to measure blood flow. We found that 20 minutes of ischemia/compression periods induces reversible hindlimb motor function damage. However, 40 minutes of that produces irreversible paralysis. The mechanisms of the damage include inflammation induced by proliferated and activated microglia, apoptosis in neuron and oligodendrocyte and blood-spinal cord barrier damage.

我们利用一种新型的血流量测量装置，能够实时观察受压部位的血流量，并获得大鼠脊髓损伤模型的临界压缩力（20g）。我们发现20分钟的缺血/压缩期可引起可逆的后肢运动功能损伤。然而，40分钟就会造成不可逆转的瘫痪。损伤的机制包括小胶质细胞增殖和活化引起的炎症、神经元和少突胶质细胞的凋亡以及血脊髓屏障的损伤。

项目成果

Prostaglandin E1 analog increases spinal cord blood flow at the point of compression during and after experimental spinal cord injury

• DOI: 10.1038/sc.2009.99
• 发表时间: 2010-02-01
• 期刊: SPINAL CORD
• 影响因子: 2.2
• 作者: Hamamoto, Y.;Ogata, T.;Yamamoto, H.
• 通讯作者: Yamamoto, H.

脊髄一過性虚血後の組織学的変化:神経血管関門の障害と炎症・アポトーシスについて

脊髓短暂缺血后的组织学变化：神经血管屏障受损、炎症和细胞凋亡

• 发表时间: 2007
• 作者: 吉村典子;阿久根徹;村木重之;岡敬之;川口浩;中村耕三;Lau EMC;Kwok A; Leung PC;森野忠夫
• 通讯作者: 森野忠夫

Real-time direct measurement of spinal cord blood flow at the site of compression - Relationship between blood flow recovery and motor deficiency in spinal cord injury

• DOI: 10.1097/brs.0b013e3181316310
• 发表时间: 2007-08-15
• 期刊: SPINE
• 影响因子: 3
• 作者: Hamamoto, Yuichiro;Ogata, Tadanori;Yamamoto, Haruyasu
• 通讯作者: Yamamoto, Haruyasu

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Real-time direct measurement of spinal cord blood flow at the compression part : relationship between blood flow and motor deficiency in the spinal cord injury

实时直接测量受压部位脊髓血流量：脊髓损伤时血流量与运动缺陷的关系

• 发表时间: 2006
• 作者: Hamamoto Y;Ogata T;Morino T;Hino M;Yamamoto H
• 通讯作者: Yamamoto H