The Research of Intracellular Energy-Related Metabolic Regulatory Enzymes on Delayed Neuronal Cell Death
The Research of Intracellular Energy-Related Metabolic Regulatory Enzymes on Delayed Neuronal Cell Death
批准号:
20591806
负责人:
FUKUDA Shiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The tendency of increasing in p-AMPKα2 and p-AMPKβ1 was observed in the brain samples 60 minutes after decapitation of rats. This result suggested that AMPK was activated by neuronal ischemia. Infarction volumes in focal ischemia with rat model were decreased by AICAR, which is one of the activators of AMPK. However, AICAR exacerbated neuronal damage in gerbil forebrain ischemia, and the same exacerbation was observed in the administration of Compound C, one of the AMPK inhibitors.
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会议论文
Do opioids aggravate ischemic spinal cord injury in rabbits?
阿片类药物会加重兔子缺血性脊髓损伤吗?
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[津田晃祐, 三木秀宣, 菅野伸彦, ほか, 福田 志朗]
通讯作者:
福田 志朗
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DOI:
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作者:
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