The contribution of the checkpoint genes to prostate cancer hormone resistant

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The checkpoint mechanism of the cell cycle that surrounded the transcript of the androgen receptor to the hormone resistance of the prostate cancer was analyzed. Nek6 appeared in the peculiarity in the prostate tissue, and was located in 33-34 chromosome. The amount of the Nek6 appearance decreases in androgen non-dependency prostate cancer cell LNCaP-HR with about 80% of LNCaP by 50% or less of LNCaP. The amount of appearance of Chk1 has decreased in the hormone resistance prostate cancer tissues. Moreover, it was a gene that Nek6 is located in the upstream of Chk1 because Nek6 induced the appearance of Chk1 and the phosphorylation of Chk1 with in vitro, and the possibility of controlling S period by the appearance of RNR was suggested.