Study for mechanisms and treatments of cochlear injury induced by ototoxic agents

耳毒性药物致耳蜗损伤的机制及治疗研究

• 批准号: 20591969
• 负责人: TABUCHI Keiji
• 金额: $ 2.91万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591969/
• 关键词: 蝸牛; ゲンタマイシン; neurosteroid; estradiol; dehydroepiandrosterone; progesterone; ガングリオシド; ceramide; 耳毒性; 内耳性障害; 内耳性音響性障害; 虚血性障害; GABA受容体; アデノシン受容体

Protective effects of nerustroids including estrogens on cochlear injury induced by ototoxic agents were reported. Estrogens protected the cochlea via c-jun-N-terminal kinase pathway. Dehydroepiandrosterone exhibited the protective effects against aminoglycoside ototoxicity. Protective effects of gagliosides and sphingosine-1-phosphate were also reported. However, ceramide exacerbated the cochlear injury induced by animoglycosides.

本文报道了包括雌激素在内的神经甾类化合物对耳毒性药物所致耳蜗损伤的保护作用。雌激素通过c-jun-N-末端激酶途径保护耳蜗。脱氢表雄酮对氨基糖苷类耳毒性有保护作用。还报道了神经节苷脂和1-磷酸鞘氨醇的保护作用。但神经酰胺加重了氨基糖苷类药物对耳蜗的损伤。

项目成果

加齢に伴う難聴におけるNrf2、peroxiredoxin1の影響

Nrf2 和过氧化还原蛋白 1 对年龄相关性听力损失的影响

• 发表时间: 2008
• 作者: 田渕経司;星野朝文;他
• 通讯作者: 他

L-type voltage-gated calcium channel is involved in the pathogenesis of acoustic injury in the cochlea.

L型电压门控钙通道参与耳蜗声损伤的发病机制。

• 发表时间: 2009
• 期刊: Tohoku J Exp Med 218(1)
• 作者: Uemaetomari I;Tabuchi K;et al
• 通讯作者: et al

The protective effect of calcium blockers against acoustic injury of the mouse cochlea

钙阻滞剂对小鼠耳蜗声损伤的保护作用

• 发表时间: 2009
• 期刊: Tohoku J Exp Med (In press)
• 作者: Uemaetomari I;Tabuchi K ;et al.
• 通讯作者: et al.

Protective effects of neurosteroids on cochlear injury

神经类固醇对耳蜗损伤的保护作用

• 发表时间: 2010
• 作者: Tabuchi K;et al.
• 通讯作者: et al.

Protective effect of calmodulin blockers in acoustic injury of the mouse.

钙调蛋白阻滞剂对小鼠声损伤的保护作用。

• 发表时间: 2010
• 作者: Uemaetomari I;Tabuchi K;Nakamagoe M;Nishimura B;Hayashi K;Tanaka S;Tsuji S;Hara A
• 通讯作者: Hara A