Study to establish a new concept of vertigo based on morphological change of cupula.

基于杯顶形态变化建立眩晕新概念的研究

• 批准号: 22591890
• 负责人: SUZUKI Mamoru
• 金额: $ 3万
• 依托单位: Tokyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591890/
• 关键词: めまい; クプラ; 半規管; 形態異常; 内耳障害; 感覚上皮障害; 血流障害; 前庭動脈; 末梢性めまい; ゲンタマイシン; 温度眼振反応; 活動電位; 電子顕微鏡

Insults, such as injection of the ototoxic drugs, rupture of the membranous labyrinth and occlusion of the vestibular artery resulted in various degrees of the cupularshrinkage. Particularly, artery occlusion caused the rapid and severe changes. The sensory epithelial change developed earlier than that of the cupula. These results indicate that the cupular change can be a cause of vertigo and circulation disorder induces acute and severe vertigo. For the cases with high risk circulation disorder, circulation should be improved as early as possible. When drug treatment is not effective, early rehabilitation is recommended.

耳毒性药物注射、膜迷路破裂、前庭动脉闭塞等损伤可导致不同程度的壶腹萎缩。特别是动脉闭塞引起的变化迅速而严重。感觉上皮的变化早于吸盘的变化。结果提示，脑杯改变可能是眩晕的原因之一，循环障碍可导致急性和严重的眩晕。对于高危循环障碍的病例，应尽早改善循环。当药物治疗无效时，建议早期康复。

项目成果

Abnormal eye movement and its management in suspected autoimmune inner ear disease

疑似自身免疫性内耳疾病的眼球运动异常及其处理

• 发表时间: 2012
• 作者: Haginomori S;Wada S;Takamaki A;Kanazawa A;Nonaka R;Takenaka H;Takubo T;Suzuki M
• 通讯作者: Suzuki M

膜迷路障害モデルにおける前庭器の変化-クプラと半規管神経活動電位の比較検討-

膜迷路障碍模型中前庭器的变化-杯托和半规管神经动作电位的比较研究-

• 发表时间: 2011
• 作者: 近藤貴仁;鈴木衞;許斐氏元;大塚康司;稲垣太郎;清水重敬;小川恭生
• 通讯作者: 小川恭生

Effect of morphological cupula change on the ampullary nerve activity.

壶腹形态变化对壶腹神经活动的影响。

• 发表时间: 2010
• 作者: Inagaki T;Suzuki M;Iimura Y;Otsuka K;Shimizu S;Konomi U;Ogawa Y
• 通讯作者: Ogawa Y

Morphological change of the cupula and its effect on the semicircular canal activity

杯托的形态变化及其对半规管活动的影响

• 发表时间: 2010
• 作者: Suzuki M;Konomi U;Otsuka K;Iimura Y;Inagaki T;Kondo T;Ogawa Y
• 通讯作者: Ogawa Y

Translational labyrinthine model for understanding BPPV etiology

用于理解 BPPV 病因的转化迷宫模型

• 作者: Suzuki M;Iimura Y;Konomi U;Otsuka K,Inagaki T;Shimizu S;Ogawa Y;河野公一;稲垣太郎,鈴木衞,飯村陽一,大塚康司,清水重敬,許斐氏元;Suzuki M;Suzuki M;Suzuki M;Suzuki M
• 通讯作者: Suzuki M