Study to establish a new concept of vertigo based on morphological change of cupula.

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Insults, such as injection of the ototoxic drugs, rupture of the membranous labyrinth and occlusion of the vestibular artery resulted in various degrees of the cupularshrinkage. Particularly, artery occlusion caused the rapid and severe changes. The sensory epithelial change developed earlier than that of the cupula. These results indicate that the cupular change can be a cause of vertigo and circulation disorder induces acute and severe vertigo. For the cases with high risk circulation disorder, circulation should be improved as early as possible. When drug treatment is not effective, early rehabilitation is recommended.