Molecular pathogenesis of middle ear mucosal proliferation during bacterial otitis media

我们使用基因阵列来评估暴露于流感嗜血杆菌后最初24小时小鼠中耳中的基因表达。我们观察到513个转录本在接种3h后显著上调，只有2个转录本下调。6h时，658个转录本上调，188个转录本下调。细菌暴露24h后，1350个转录本表达增加，1632个转录本表达减少。

We used gene array to assess gene expression in the mouse middle ear in the first 24h following exposure to Haemophilus influenzae. We observed 513 transcripts that were significantly up-regulated 3h after inoculation, while only 2 transcripts were down-regulated. At 6h, 658 up-regulated transcripts were noted, as compared to 188 down-regulated genes. By 24h after bacterial exposure, 1350 transcripts showed increased expression while 1632 exhibited reduced expression.