The relationship between the periodicity of incremental lines in the tooth dentin and a biological clock : Regulation by melatonin

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It became clear that the melatonin receptors MT1 and MT2 were present in the tooth embryo. The level of melatonin concentration during the night time was higher than that of the daytime. The dark-staining layer of hematoxylin was observed at the calcification front of dentin formed during the night time. It is considered that calcification advances during night periods, when the dark-staining layer of hematoxylin is formed, while the light-staining layer is formed during the daytime. It is suggested that melatonin may participate in the periodicity of the incremental lines of dentin.