The relationship between the periodicity of incremental lines in the tooth dentin and a biological clock : Regulation by melatonin

牙齿牙本质增量线的周期性与生物钟之间的关系：褪黑激素的调节

• 批准号: 20592168
• 负责人: MISHIMA Hiroyuki
• 金额: $ 3万
• 依托单位: Kochi Gakuen College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592168/
• 关键词: 遺伝子; 細胞・組織; 歯学; 成長線; メラトニン

It became clear that the melatonin receptors MT1 and MT2 were present in the tooth embryo. The level of melatonin concentration during the night time was higher than that of the daytime. The dark-staining layer of hematoxylin was observed at the calcification front of dentin formed during the night time. It is considered that calcification advances during night periods, when the dark-staining layer of hematoxylin is formed, while the light-staining layer is formed during the daytime. It is suggested that melatonin may participate in the periodicity of the incremental lines of dentin.

很明显，褪黑素受体MT1和MT2存在于牙齿胚胎中。褪黑激素浓度夜间高于白天。夜间形成的牙本质钙化前沿可见苏木素深染层。据认为，钙化在夜间推进，此时形成苏木素的深色着色层，而浅染色层在白天形成。提示褪黑素可能参与了牙本质增殖线的周期性变化。

项目成果

根尖部膿胞部に形成された根尖部歯石のX線解析

根尖脓疱区域形成的根尖牙结石的 X 射线分析

• 发表时间: 2009
• 期刊: 歯界展望 特別号
• 作者: 三島弘幸;大久保厚司;宮元沙織;北原正大;和食沙紀;大野由香;中石裕子;野村加代
• 通讯作者: 野村加代

象牙質の成長線の性状とその形成リズム

牙本质生长线的特性及其形成节律

• 发表时间: 2010
• 作者: 三島弘幸;北原正大;服部淳彦;鈴木信雄;田畑純;奈良雅之;筧光夫;見明康雄
• 通讯作者: 見明康雄

Possible involvement of melatonin in the relationship between biological rhythm and periodicity of incremental line formation in the dentin of teeth

褪黑激素可能参与生物节律和牙齿牙本质增量线形成周期性之间的关系

• 发表时间: 2010
• 作者: H Mishima;M Kitahara;A Hattori;N Suzuki;M J.Tabata;M Kakei;Y Miake
• 通讯作者: Y Miake

Transmission electron microscopy of vascular calcification

血管钙化的透射电子显微镜

• 发表时间: 2010
• 作者: M.Kakei;T.Sakae;H.Mishima;M.Yoshikawa
• 通讯作者: M.Yoshikawa

動脈および歯石における石灰化過程について

关于动脉和牙结石的钙化过程

• 发表时间: 2010
• 作者: 覧光夫;寒河江登志朗;三島弘幸;吉川正芳
• 通讯作者: 吉川正芳