The connection between the periodicity incremental lines of dentin and the secretion rhythm of melatonin of the signaling molecules of biological clock

牙本质周期性增量线与生物钟信号分子褪黑素分泌节律的关系

• 批准号: 23592727
• 负责人: MISHIMA Hiroyuki
• 金额: $ 3.41万
• 依托单位: Kochi Gakuen College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592727/
• 关键词: 象牙質; メラトニン; 成長線; 体内時計; SEM-EDS; サーカディアンリズム; SEM-EDS分析; ラマン分光; 歯学; 生物時計; 細胞・組織; 遺伝子

The purpose of the present study is to examine the relationship between the periodicity of incremental lines in dentin of teeth and the role of melatonin that the signaling molecules of biological clock. In this experiment, 5- and 6-day, 7- and 8-days after birth SD rats were used. In the low melatonin concentration group, the light staining layer became narrow. In the high melatonin concentration group, this layer disappeared. The number and size of calcospherites in predentin increased in proportion to the concentration of melatonin administered. The new incremental line was confirmed in both the incisor and molar dentin of the melatonin treated groups. In SEM-EDS analysis, Ca and P content were increasing by the melatonin treated group compared with the control group. It is considered that melatonin participates in the formation of incremental lines and the calcification mechanism of the odontoblast.

本研究旨在探讨生物钟信号分子褪黑激素与牙本质生长线周期性的关系。本实验选用生后5、6、7、8天的SD大鼠。在低浓度褪黑素组中，光染色层变窄。在高褪黑素浓度组中，该层消失。前牙本质中钙球的数量和大小与褪黑激素的浓度成比例增加。新的增量线在褪黑激素治疗组的切牙和磨牙牙本质中得到证实。在SEM-EDS分析中，与对照组相比，褪黑素处理组的Ca和P含量增加。认为褪黑素参与成牙本质细胞增殖线的形成和钙化机制。

项目成果

Eusthenopteron foodi（カナダ産デボン紀）の歯の組織構造と槽生性結合

Eusthenopteron foodi（加拿大泥盆纪）的牙齿结构和牙槽连接

• 发表时间: 2014
• 作者: 三島弘幸;筧光夫;門田理佳;見明康雄;笹川一郎
• 通讯作者: 笹川一郎

Tooth and dermal exoskeleton of Eusthenopteron from Devonian

泥盆纪真翅目动物的牙齿和真皮外骨骼

• 发表时间: 2013
• 作者: H。Mishima;M。Kakei;I。Sasagawa;K。Matsui;Y。Miake
• 通讯作者: Y。Miake

カナダ産デボン紀Eusthenopteron foodiの歯と皮甲の組織構造と組成

加拿大泥盆纪Eusthenopteron foodi牙齿和甲壳的组织结构及成分

• 发表时间: 2011
• 作者: 三島弘幸;徳弘将光;筧光夫;安井敏夫;見明康雄
• 通讯作者: 見明康雄

生体アパタイトの形成機構(中心線経路)とイタイイタイ病に関する考察

生物磷灰石（中心线通路）形成机制与痛痛病的探讨

• 发表时间: 2011
• 作者: 筧光夫;寒河江登志朗;三島弘幸;吉川正芳
• 通讯作者: 吉川正芳

Parathyroid hormone 1 (1-34) acts on the scales and involves calcium metabolism in goldfish

• DOI: 10.1016/j.bone.2011.02.004
• 发表时间: 2011-05-01
• 期刊: BONE
• 影响因子: 4.1
• 作者: Suzuki, Nobuo;Danks, Janine A.;Martin, T. John
• 通讯作者: Martin, T. John