Study on a therapeutic application of tea catechins to vital pulp treatment.

茶儿茶素在活髓治疗中的应用研究。

• 批准号: 20592228
• 负责人: NAKANISHI Tadashi
• 金额: $ 3万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592228/
• 关键词: カテキン; 歯髄炎; 歯髄細胞; 抗炎症作用; サイトカイン; ケモカイン; シグナル伝達経路

Caries progression induces pulp tissue to inflammation, which can develop pulpitis. The treatment for severe pulpitis is commonly pulpectomy, but it is thought that teeth stripped of pulp increased fracture risk in the future. The purpose of this study was development of the pulp preservation therapy using catechin, and we evaluated the effect of catechins on dental pulp cells stimulated with various bacteria-related factors. As a result, we showed that the catechins inhibited the expression of inflammatory factors in the dental pulp cells, and this finding suggested that they could be applied in the treatment of pulpitis.

龋病的进展诱导牙髓组织炎症，这可以发展为牙髓炎。严重牙髓炎的治疗通常是牙髓切除术，但据认为，牙髓剥离牙齿增加了未来骨折的风险。本研究的目的是开发使用儿茶素的牙髓保存疗法，并评估儿茶素对各种细菌相关因子刺激的牙髓细胞的影响。结果表明，儿茶素可抑制牙髓细胞中炎症因子的表达，这一发现表明它们可用于治疗牙髓炎。

项目成果

カテキンがヒト培養歯髄細胞のサイトカイン産生に与える影響 ～石灰化誘導培地を用いた環境下において～

儿茶素对培养的人牙髓细胞细胞因子产生的影响 - 在使用矿化诱导培养基的环境下 -

• 发表时间: 2008
• 作者: 向井佳代;他
• 通讯作者: 他

Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells

• DOI: 10.1016/j.lfs.2010.02.017
• 发表时间: 2010-04-24
• 期刊: LIFE SCIENCES
• 影响因子: 6.1
• 作者: Hirao, Kouji;Yumoto, Hiromichi;Matsuo, Takashi
• 通讯作者: Matsuo, Takashi

歯髄炎の病態形成における細菌侵襲と歯髄の反応性

牙髓炎发病机制中的细菌侵入和牙髓反应性

• 发表时间: 2010
• 期刊: 日歯保存誌 53
• 作者: Iwashita M.;Kumamoto S.;Kushiyama A.;Nakatsu Y.;Tsuchiya Y.;Sakoda H.;Fujishiro M.;Otani Y.;Kikuchi T.;Nishimura F.;Kamata H.;Asano T.;中西正
• 通讯作者: 中西正

Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors

• DOI: 10.1111/j.1600-0722.2010.00714.x
• 发表时间: 2010-04-01
• 期刊: EUROPEAN JOURNAL OF ORAL SCIENCES
• 影响因子: 1.9
• 作者: Nakanishi, Tadashi;Mukai, Kayo;Matsuo, Takashi
• 通讯作者: Matsuo, Takashi

Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts

• DOI: 10.1002/mnfr.200900549
• 发表时间: 2010-07-01
• 期刊: MOLECULAR NUTRITION & FOOD RESEARCH
• 影响因子: 5.2
• 作者: Hosokawa, Yoshitaka;Hosokawa, Ikuko;Matsuo, Takashi
• 通讯作者: Matsuo, Takashi