Regulate for invasiveness by epithelial?mesenchymal interaction of oral cancer.

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We examined the target molecule of the molecular target treatment with the goal of a metastasis control.by using the fibronectin resolution/invasion model that could observe the extracellular matrix resolution due to the cancer cell in vitro. We used the OSC-19 cells which were cell line derived from two kinds of different human oral squamous cell carcinomas of the invasion style and OSC-20 cells. The reptin gene knockdown cells and compared cellular infiltration/the migration ability and compared the manifestation of the transcriptional regulator of activity of the basal membrane splitting enzyme, manifestation of small molecule GTP-binding protein, epithelial mesenchymal transition (EMT) related protein and EMT.