Type of bone invasion in human or al squamous cell carcinoma and its mechanisms ; application for molecular diagnosis

人类或鳞状细胞癌的骨侵犯类型及其机制；

• 批准号: 20592356
• 负责人: NOGUCHI Makoto
• 金额: $ 2.91万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592356/
• 关键词: 口腔扁平上皮癌; 顎骨浸潤; 破骨細胞; 破骨細胞分化誘導因子; ビスホスホネート製剤; アポトーシス; 扁平上皮癌; ピスホスホネート製; ピスホスホネート製剤; アポートシス

We immunohistochemically observed expression of various kinds of cytokines related to osteoclastic differentiation in human squamous cell carcioma of the lower gum. Over-expression of RANKL or OPG could be barely seen in cancer cells, although PTHrP was slightly expressed. The relationship between type of bone invasion and expression of them has failed to clarify.Using oral squamous cancer cell lines, over-expression of MMP9 or periostin was strongly observed in high invasive cell line (HSC4) compared with low invasive cell line (HSC3). Apoptosis was induced in HSC4 cells with low dose bisphosphonate. Moreover, induction of apoptosis in cell line was enhanced by addition to Ca.

我们用免疫组织化学方法观察了与破骨细胞分化相关的各种细胞因子在人下牙龈鳞状细胞癌中的表达。虽然PTHrP有少量表达，但RANKL和OPG在癌细胞中几乎没有过表达。MMP9和Periostin在高侵袭性细胞系(HSC4)和低侵袭性细胞系(HSC3)中高表达。小剂量双膦酸盐可诱导HSC4细胞发生凋亡。此外，钙还可促进细胞的凋亡诱导。

项目成果

口腔扁平上皮癌細胞株における低濃度ビスフォスフォの抗腫瘍効果

低浓度二磷酸对口腔鳞状细胞癌细胞系的抗肿瘤作用

• 发表时间: 2011
• 作者: 井上さやか;新井直也;野口誠
• 通讯作者: 野口誠

下顎歯肉扁平上皮癌の臨床病理学的研究.

下颌牙龈鳞状细胞癌的临床病理学研究。

• 发表时间: 2008
• 作者: 能登久美子;朽名智彦;金佳美;上田耕平;井上さやか;野口誠
• 通讯作者: 野口誠

Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves

• DOI: 10.1111/j.1529-8027.2009.00228.x
• 发表时间: 2009-09-01
• 期刊: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
• 影响因子: 3.8
• 作者: Yamazaki, Takashi;Sabit, Hemragul;Sasahara, Masakiyo
• 通讯作者: Sasahara, Masakiyo

A strategy for organ preservation in treating locally advanced oral cancer

治疗局部晚期口腔癌的器官保存策略

• 发表时间: 2010
• 作者: NOGUCHI M.;et al.
• 通讯作者: et al.

A strategy for organ preservation in treating of locally advanced oral cancer.

治疗局部晚期口腔癌的器官保存策略。

• 发表时间: 2010
• 作者: Noguchi M.;Tsuno H.;Imaue S.;Ohura T.;Inoue S.;Arai N.
• 通讯作者: Arai N.