Type of bone invasion in human or al squamous cell carcinoma and its mechanisms ; application for molecular diagnosis
Type of bone invasion in human or al squamous cell carcinoma and its mechanisms ; application for molecular diagnosis
批准号:
20592356
负责人:
NOGUCHI Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We immunohistochemically observed expression of various kinds of cytokines related to osteoclastic differentiation in human squamous cell carcioma of the lower gum. Over-expression of RANKL or OPG could be barely seen in cancer cells, although PTHrP was slightly expressed. The relationship between type of bone invasion and expression of them has failed to clarify.Using oral squamous cancer cell lines, over-expression of MMP9 or periostin was strongly observed in high invasive cell line (HSC4) compared with low invasive cell line (HSC3). Apoptosis was induced in HSC4 cells with low dose bisphosphonate. Moreover, induction of apoptosis in cell line was enhanced by addition to Ca.
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口腔扁平上皮癌細胞株における低濃度ビスフォスフォの抗腫瘍効果
低浓度二磷酸对口腔鳞状细胞癌细胞系的抗肿瘤作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[井上さやか, 新井直也, 野口誠]
通讯作者:
野口誠
下顎歯肉扁平上皮癌の臨床病理学的研究.
下颌牙龈鳞状细胞癌的临床病理学研究。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[能登久美子, 朽名智彦, 金佳美, 上田耕平, 井上さやか, 野口誠]
通讯作者:
野口誠
DOI:
10.1111/j.1529-8027.2009.00228.x
发表时间:
2009-09-01
期刊:
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
影响因子:
3.8
作者:
[Yamazaki, Takashi, Sabit, Hemragul, Sasahara, Masakiyo]
通讯作者:
Sasahara, Masakiyo
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[NOGUCHI M., et al.]
通讯作者:
et al.
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Noguchi M., Tsuno H., Imaue S., Ohura T., Inoue S., Arai N.]
通讯作者:
Arai N.
共 8 条
A novel strategy against bone invasion of oral cancer
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批准号:23592957
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
-
财政年份:2011
-
负责人:NOGUCHI Makoto
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依托单位:
THE DEVELOPMENT OF A GENE-BASED DIAGNOSTIC METHOD TO EVALUATE THE EFFICACY OF PRE-CHEMOTHERAPUTIC AGENTS IN ORAL CANCER THAT ALTER GENE EXPRESSION BY AFFECTING DNA METHYLATION
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批准号:15592121
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:NOGUCHI Makoto
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依托单位:
STUDY ON CHARACTERISTICS OF TUMOR CELLS AND MICRO ENVIROMENTAL FACTORS OF HIGHLY INVASIVE ORAL SQUAMOUS CELL CARCINOMA
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批准号:08457553
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.42万
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财政年份:1996
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负责人:NOGUCHI Makoto
-
依托单位:
海外基金